Plasmodium falciparum; merozoite invasion rate in erythrocytes with b-thalassaemia trait and glucose-6-phosphate dehydrogenase deficient genes

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dc.contributor.authorMyat Phone Kyawen_US
dc.contributor.authorMyint Ooen_US
dc.contributor.authorKyin Hla Ayeen_US
dc.date.accessioned2009-06-30T09:02:27Z
dc.date.available2009-06-30T09:02:27Z
dc.date.created1993-04-01en_US
dc.date.issued1993-04-01en_US
dc.description.abstractThe malaria parasite invasion-erythrocyte membrane protein variation hypothesis was tested on red cells collected from subjects with G-6-PD deficiency and -thalassaemia trait genes. A series of in vitro competition assays were carried out by using serial dilution technique and the FITC-labelling method (1). The results showed that the invasion rates of P. falciparum merozoites into two G-6-PD hemizygotes deficient cell were Gd- 100 Percent of normal and Gd-Myanmar 95 Percent of normal. But in erythrocytes from two patients with double gene defects viz. G-6-PD mild deficient gene GdB-with -thalassaemia trait gene was 25 Percent and G-6-PD severely deficient gene Gd-Myanmar with -thalassaemia trait gene was 20 Percent susceptible to merozoite invasion. The invasion rate of malaria merozoites in these cells could be inhibited by the partial loss of vital attachement of the red cell membrane required for the process of invasion.en_US
dc.identifier.citationMyat Phone Kyaw, Myint Oo, Kyin Hla Aye. Plasmodium falciparum; merozoite invasion rate in erythrocytes with b-thalassaemia trait and glucose-6-phosphate dehydrogenase deficient genes. Myanmar Health Sciences Research Journal. 1993; 5(1): 13-18en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/127084
dc.subject.meshPlasmodium Falciparumen_US
dc.subject.meshThalassemiaen_US
dc.subject.meshGlucogen Storage Disease Type Ien_US
dc.subject.meshErythrocytesen_US
dc.subject.meshGenesen_US
dc.subject.meshMyanmaren_US
dc.titlePlasmodium falciparum; merozoite invasion rate in erythrocytes with b-thalassaemia trait and glucose-6-phosphate dehydrogenase deficient genesen_US
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