Lipid peroxidation in plumbagin administered rats.
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Date
1987-09
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Abstract
Plumbagin was administered to rats at a concentration of 1,2,4,8 and 16 mg per
kg body weight. After 24 h lipid peroxide levels were found to decrease in subcellular
fractions of liver. Plumbagin inhibited ascorbate and nicotinafde adenine dinucleotide
phosphate (reduced) dependent lipid peroxidation but was without any effect on cumene
hydroperoxide dependent lipid peroxidation. Injection of 16 mg of plumbagin per kg body
weight was found to decrease liver total reduced glutathione and also fcrosomal glucose-
6-phosphatase. The results are discussed with reference to the anti- and prooxidant
properties of plumbagin.
Description
Keywords
Plumbagin, lipid peroxidation, glutathione, glucose-6-phosphatase
Citation
Sankar R, Devamanoharan P S, Raghupathi G, Krishnasamy M, Devi C S Shyamala. Lipid peroxidation in plumbagin administered rats. Journal of Biosciences. 1987 Sept; 12(3): 267-271.