Evidence based review on levosalbutamol.

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dc.contributor.authorGupta, Mukesh Kumaren_US
dc.contributor.authorSingh, Meenuen_US
dc.date.accessioned2007-02-06en_US
dc.date.accessioned2009-05-30T16:14:46Z
dc.date.available2007-02-06en_US
dc.date.available2009-05-30T16:14:46Z
dc.date.issued2007-02-06en_US
dc.description35 references.en_US
dc.description.abstractSalbutamol, the most commonly used bronchodilator, is a chiral drug with R (levosalbutamol) and S-isomers (also known as enantiomer). The commonly used formulation is a racemic mixture that contains equal amounts of both R and S isomers. Levosalbutamol is the therapeutically active isomer and has all the beta 2 agonist activity. Until recently S-salbutamol was considered inert filler in the racemic mixture but animal as well as human studies have shown that S-salbutamol is not inert rather it may have some deleterious effects. Enantioselective metabolism of salbutamol leads to higher and sustained plasma levels of S-salbutamol with repeated dosing. There has been concern that chronic use of racemic salbutamol may lead to loss of effectiveness and clinical deterioration. Formulation of salbutamol containing only R- isomer (levosalbutamol) has been available in international market since last few years. Clinical trials in acute as well as chronic asthma in adults as well as children have shown that it has therapeutic advantage over racemic salbutamol and also is more cost effective. But, large multicenter trials are needed to prove its therapeutic superiority and cost-effectiveness in long term.en_US
dc.description.affiliationDepartment of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India. mukesh_dhonkaria@yahoo.co.inen_US
dc.identifier.citationGupta MK, Singh M. Evidence based review on levosalbutamol. Indian Journal of Pediatrics. 2007 Feb; 74(2): 161-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/84384
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdministration, Inhalationen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdrenergic beta-Agonists --administration & dosageen_US
dc.subject.meshAlbuterol --administration & dosageen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAsthma --diagnosisen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshEvidence-Based Medicineen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshQuality of Lifeen_US
dc.subject.meshRandomized Controlled Trials as Topicen_US
dc.subject.meshRespiratory Function Testsen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEvidence based review on levosalbutamol.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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