Acute encephalitis with flaccid paralysis following an adenoviral infection presenting as a rare variant of Guillain Barre syndrome in a school-age child

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dc.contributor.authorLoni, Ren_US
dc.contributor.authorAlsindi, AMen_US
dc.contributor.authorAlfaw, AAen_US
dc.contributor.authorFox, GPen_US
dc.contributor.authorAbbas, Ien_US
dc.contributor.authorLambert, IMen_US
dc.contributor.authorLynch, B.en_US
dc.date.accessioned2025-05-09T11:05:36Z
dc.date.available2025-05-09T11:05:36Z
dc.date.issued2024-08
dc.description.abstractGuillain-Barre syndrome (GBS), Miller-Fisher syndrome (MFS), and Bickerstaff抯 brainstem encephalitis (BBE) are syndromes which represent a spectrum of post-infectious inflammatory immune-mediated diseases. They may share a common autoimmune pathogenetic mechanism presenting with progressive ascending weakness or flaccid paralysis affecting both pediatric as well as adult populations. MFS and BBE are rare variants of GBS that should be part of the differential diagnosis when relevant features are present. We present a case of a 6-year-old boy, presenting with a sore throat of one-day duration, associated with difficulty in swallowing, increased salivation and drooling, inability to speak or swallow following an adenoviral upper respiratory infection with exudative tonsillitis and diarrhea. Clinical evaluation showed weak gag reflex and cough reflex, hyperreflexia without clonus, upgoing Babinski reflexes, and hypotonia. A diagnosis of BBE was made based on specific neurological manifestations of hyperreflexia and drowsiness, serological studies, and MRI findings.en_US
dc.identifier.affiliationsPICU, King Hamad University Hospital, Bahrainen_US
dc.identifier.affiliationsDepartment of Paediatrics, King Hamad University Hospital, Bahrainen_US
dc.identifier.affiliationsDepartment of Paediatrics, King Hamad University Hospital, Bahrainen_US
dc.identifier.affiliationsPICU, King Hamad University Hospital, Bahrainen_US
dc.identifier.affiliationsPICU, King Hamad University Hospital, Bahrainen_US
dc.identifier.affiliationsDepartment of Paediatrics, King Hamad University Hospital, Bahrainen_US
dc.identifier.affiliationsChildrens Health at Temple St, Dublin, Irelanden_US
dc.identifier.citationLoni R, Alsindi AM, Alfaw AA, Fox GP, Abbas I, Lambert IM, Lynch B.. Acute encephalitis with flaccid paralysis following an adenoviral infection presenting as a rare variant of Guillain Barre syndrome in a school-age child . International Journal of Contemporary Pediatrics. 2024 Aug; 11(8): 1123-1128en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246252
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber8en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.18203/2349-3291.ijcp20241944en_US
dc.subjectBickerstaff encephalitisen_US
dc.subjectGBSen_US
dc.subjectChilden_US
dc.subjectBulbar palsyen_US
dc.subjectGanglioside GM2 antibodiesen_US
dc.titleAcute encephalitis with flaccid paralysis following an adenoviral infection presenting as a rare variant of Guillain Barre syndrome in a school-age childen_US
dc.typeJournal Articleen_US
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