Profile of liver involvement in dengue virus infection.

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dc.contributor.authorItha, Srivenuen_US
dc.contributor.authorKashyap, Rajeshen_US
dc.contributor.authorKrishnani, Narendraen_US
dc.contributor.authorSaraswat, Vivek Aen_US
dc.contributor.authorChoudhuri, Gourdasen_US
dc.contributor.authorAggarwal, Rakeshen_US
dc.date.accessioned2005-05-01en_US
dc.date.accessioned2009-06-03T07:05:21Z
dc.date.available2005-05-01en_US
dc.date.available2009-06-03T07:05:21Z
dc.date.issued2005-05-01en_US
dc.description.abstractBACKGROUND: Data are scarce on liver involvement in adult patients with dengue virus infection. METHODS: During a recent outbreak of dengue fever in Uttar Pradesh, India, we looked for evidence of liver dysfunction among patients with dengue fever. RESULTS: A total of 45 patients with dengue fever (age 7-65 [median 33] years; 29 men; 39 adults) were studied, including 23 with uncomplicated dengue fever, 15 with dengue haemorrhagic fever and 7 with dengue shock syndrome. The median platelet count was 34 x 10(9)/L (9-99 x 10(9)). Seven patients (15%) had jaundice, 11 (24%) hepatomegaly and 9 clinically detectable ascites; none had splenomegaly. Twelve patients (30%) had hyperbilirubinaemia. Serum alanine and aspartate aminotransferase activities were elevated in 43 patients (96%) each; 5-fold elevated levels were more frequent in severe disease. Hypoalbuminaemia was found in 31/41 patients (76%). Seven patients died, including 2 with acute liver failure. CONCLUSION: Our data show that liver injury is common in adult patients with dengue infection. Further studies are needed to determine the mechanism of liver injury in this disease.en_US
dc.description.affiliationSanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow 226014, Uttar Pradesh, India.en_US
dc.identifier.citationItha S, Kashyap R, Krishnani N, Saraswat VA, Choudhuri G, Aggarwal R. Profile of liver involvement in dengue virus infection. National Medical Journal of India. 2005 May-Jun; 18(3): 127-30en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/119479
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChilden_US
dc.subject.meshDengue --complicationsen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshLiver Diseases --etiologyen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleProfile of liver involvement in dengue virus infection.en_US
dc.typeJournal Articleen_US
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