Profile of liver involvement in dengue virus infection.
dc.contributor.author | Itha, Srivenu | en_US |
dc.contributor.author | Kashyap, Rajesh | en_US |
dc.contributor.author | Krishnani, Narendra | en_US |
dc.contributor.author | Saraswat, Vivek A | en_US |
dc.contributor.author | Choudhuri, Gourdas | en_US |
dc.contributor.author | Aggarwal, Rakesh | en_US |
dc.date.accessioned | 2005-05-01 | en_US |
dc.date.accessioned | 2009-06-03T07:05:21Z | |
dc.date.available | 2005-05-01 | en_US |
dc.date.available | 2009-06-03T07:05:21Z | |
dc.date.issued | 2005-05-01 | en_US |
dc.description.abstract | BACKGROUND: Data are scarce on liver involvement in adult patients with dengue virus infection. METHODS: During a recent outbreak of dengue fever in Uttar Pradesh, India, we looked for evidence of liver dysfunction among patients with dengue fever. RESULTS: A total of 45 patients with dengue fever (age 7-65 [median 33] years; 29 men; 39 adults) were studied, including 23 with uncomplicated dengue fever, 15 with dengue haemorrhagic fever and 7 with dengue shock syndrome. The median platelet count was 34 x 10(9)/L (9-99 x 10(9)). Seven patients (15%) had jaundice, 11 (24%) hepatomegaly and 9 clinically detectable ascites; none had splenomegaly. Twelve patients (30%) had hyperbilirubinaemia. Serum alanine and aspartate aminotransferase activities were elevated in 43 patients (96%) each; 5-fold elevated levels were more frequent in severe disease. Hypoalbuminaemia was found in 31/41 patients (76%). Seven patients died, including 2 with acute liver failure. CONCLUSION: Our data show that liver injury is common in adult patients with dengue infection. Further studies are needed to determine the mechanism of liver injury in this disease. | en_US |
dc.description.affiliation | Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow 226014, Uttar Pradesh, India. | en_US |
dc.identifier.citation | Itha S, Kashyap R, Krishnani N, Saraswat VA, Choudhuri G, Aggarwal R. Profile of liver involvement in dengue virus infection. National Medical Journal of India. 2005 May-Jun; 18(3): 127-30 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/119479 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.nmji.in | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Dengue --complications | en_US |
dc.subject.mesh | Disease Outbreaks | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | India --epidemiology | en_US |
dc.subject.mesh | Liver Diseases --etiology | en_US |
dc.subject.mesh | Liver Function Tests | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.title | Profile of liver involvement in dengue virus infection. | en_US |
dc.type | Journal Article | en_US |
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