Studies on oxidative stress, serum iron and iron binding capacity in subjects prone to the risk of coronary artery disease.

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dc.contributor.authorSharma, S Ben_US
dc.contributor.authorDwivedi, Sen_US
dc.contributor.authorKumar, Nen_US
dc.contributor.authorPrabhu, K Men_US
dc.contributor.authorMadan, Nen_US
dc.date.accessioned2000-09-21en_US
dc.date.accessioned2009-05-27T04:24:25Z
dc.date.available2000-09-21en_US
dc.date.available2009-05-27T04:24:25Z
dc.date.issued2000-09-21en_US
dc.description.abstractLipid peroxidation in vitro and in vivo has been postulated to be involved in the development of atherosclerosis. It is also known that free iron catalyses the lipid peroxidation. Therefore, we assessed the status of oxidative stress in smokers, hypertensives and non-insulin dependent subjects, who were prone to coronary artery disease. In addition, superoxide dismutase levels and iron binding capacity were also measured to know their antioxidant defences. One hundred seventy-five consecutive subjects below 60 years of age were examined; they were then divided into three groups: one with coronary artery disease, another without coronary artery disease and a healthy control group. The patients having either of the one risk factors for coronary artery disease i.e. smoking, hypertension and/or diabetes were studied. Serum lipid peroxides, superoxide dismutase, serum iron and iron binding capacity were estimated. Oxidative stress was highest in smokers with coronary artery disease (3.11+/-0.79 mmol/ml) as compared to hypertensives (2.69+/-0.20 mmol/nl) and non-insulin dependent diabetics (2.78+/-0.19 mmol/ml). Superoxide dismutase activity was also significantly decreased (p<0.001) in smokers with coronary artery disease as compared to hypertensives and non-insulin dependent diabetes mellitus. Final step of stepwise logistic regression based on malondialdehyde and superoxide dismutase correctly predicted coronary artery disease status in 90 percent smokers. Serum iron and total iron binding capacity were not significantly different in risk prone subjects. However, among all risk prone subjects, smokers with coronary artery disease showed highest serum iron levels and decreased iron binding capacity.en_US
dc.description.affiliationDepartment of Biochemistry, University College of Medical Sciences and GTB Hospital, Delhi.en_US
dc.identifier.citationSharma SB, Dwivedi S, Kumar N, Prabhu KM, Madan N. Studies on oxidative stress, serum iron and iron binding capacity in subjects prone to the risk of coronary artery disease. Indian Heart Journal. 2000 Sep-Oct; 52(5): 583-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4755
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdulten_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshCoronary Disease --blooden_US
dc.subject.meshDisease Susceptibilityen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIron --blooden_US
dc.subject.meshLipid Peroxides --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehyde --blooden_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSuperoxide Dismutase --blooden_US
dc.subject.meshTransferrin --metabolismen_US
dc.titleStudies on oxidative stress, serum iron and iron binding capacity in subjects prone to the risk of coronary artery disease.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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