To compare central visual field progression using mean deviation and pointwise linear regression analysis

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dc.contributor.authorPatil, Trupti Sen_US
dc.contributor.authorViswanathan, Nen_US
dc.contributor.authorGeorge, Ronnieen_US
dc.date.accessioned2023-08-25T06:36:24Z
dc.date.available2023-08-25T06:36:24Z
dc.date.issued2023-03
dc.description.abstractPurpose: To compare central visual field progression using mean deviation and pointwise linear regression (PLR) analysis. Methods: We analyzed the 10?2 Humphrey visual field (HVF) tests for moderate and advanced primary glaucoma who had undergone at least five reliable 10?2 visual field tests with a minimum follow?up of at least two years and best?corrected visual acuity better than 6/12. Regression slope less than ?1 dB/year at P < 0.01 at a point was defined as an individual threshold point progression. Results: Ninety?six eyes of 74 patients were included. The median follow?up duration was of 4 years (±1.97). Median 10?2 mean deviation (MD) at inclusion was ?19.01 dB (interquartile range [IQR] ?13.2, ?24.14) and ?21.90 (IQR ? 13.4, ?27.8) on 24?2 HVF. The median rate of MD change was ?0.13 dB/year (IQR ? 0.46, 0.08) for 10?2. The median rate for visual field index (VFI) change was 0.9% per year (IQR ? 1.5, 0.4). Twenty?eight percent of eyes (27 eyes) showed progression. Twelve percent (12 eyes) showed progression of two or more points in the same hemifield on pointwise linear regression (PLR) analysis, and 16% of eyes (15 eyes) showed progression of one point. The median rate of MD change was significantly more in progressing eyes based on PLR analysis than eyes with no progression (?0.5 vs. ?0.06 dB/year P < 0.001). One patient had likely and the second had possible progression on 24?2. In 24 eyes, event analysis did not show any change; the rest mean deviation was out of range. Conclusion: Central visual field PLR analysis is useful in detecting progression in advanced glaucomatous damage.en_US
dc.identifier.affiliationsSmt. Jadhavbai Nathamal Singhvee Glaucoma Services, Sankara Nethralaya Medical Research Foundation, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationPatil Trupti S, Viswanathan N, George Ronnie. To compare central visual field progression using mean deviation and pointwise linear regression analysis. Indian Journal of Ophthalmology. 2023 Mar; 71(3): 854-860en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224888
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber3en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1737_22en_US
dc.subject10?2 PLRen_US
dc.subjectadvanced glaucomaen_US
dc.subjectcentral visual field progressionen_US
dc.titleTo compare central visual field progression using mean deviation and pointwise linear regression analysisen_US
dc.typeJournal Articleen_US
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