Lennert's lymphoma: Clinicopathological profile of five cases.
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Date
2013-07
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Abstract
Background and Aim: Lennert’s lymphoma is a rare variant of peripheral T-cell
lymphoma (PTCL) not otherwise specifi ed (NOS) rich in epithelioid histiocytes.
This study aims to analyze the clinical, morphologic, and immunophenotypic
profi le of cases of Lennert’s lymphoma from our country and determines the
utility of T-cell receptor (TCR) gene rearrangement in the diagnosis. Materials
and Methods: All cases diagnosed as Lennert’s lymphoma during the period
of January 2001 to August 2011 were included in this study. Hematoxylin
and eosin (H and E) stained slides and immunohistochemistry results were
analyzed and TCR gene rearrangement was performed. Results: There were
fi ve cases of Lennert’s lymphoma diagnosed in our institution during this period,
which included two males and three females. All cases showed effacement
of lymph node architecture by diffuse infi ltration of small lymphoid T cells
[CD3+, CD4+, CD8+, T-cell intracellular antigen 1 (TIA-1+), Granzyme B−] and
clusters of epithelioid histiocytes throughout the lymph node and scattered large
transformed cells (CD20−, CD30+, CD15−/+). TCR rearrangement was done
in three cases by polymerase chain reaction (PCR) and showed the presence
of a clonal T-cell population. Conclusions: Lennert’s lymphoma constituted
0.11% of all non-Hodgkin lymphomas (NHLs) in our institution. Differentiation
from classical Hodgkin’s lymphoma is sometimes diffi cult by morphology and
immunohistochemistry alone and TCR gene rearrangement was extremely
useful in diagnosis.
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Keywords
Hodgkin’s lymphoma, Lennert’s lymphoma, TCR gene rearrangement
Citation
Parimal Sarda, Pai Rekha, Manipadam Marie Therese, Nair Sheila. Lennert's lymphoma: Clinicopathological profile of five cases. Indian Journal of Pathology & Microbiology. 2013 Jul-Sept 56 (3): 248-251.