Blastic plasmacytoid dendritic cell neoplasm: Report of two pediatric cases.

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dc.contributor.authorDharmani, Preeti Ashok
dc.contributor.authorMittal, Neha Manish
dc.contributor.authorSubramanian, P G
dc.contributor.authorGalani, Komal
dc.contributor.authorBadrinath, Yajamanam
dc.contributor.authorAmare, Pratibha
dc.contributor.authorGujral, Sumeet
dc.date.accessioned2015-02-20T09:39:14Z
dc.date.available2015-02-20T09:39:14Z
dc.date.issued2015-01
dc.description.abstractBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of acute leukemia that typically follows a highly aggressive clinical course in adults, whereas experience in children with this disease is very limited. We report cases of two children in whom bone marrow showed infi ltration by large atypical monocytoid ‘blast-like’ cells which on immunophenotyping expressed CD4, CD56, HLA-DR and CD33 while were negative for CD34 other T-cell, B-cell and myeloid markers. The differential diagnoses considered were AML, T/NKcell leukemia and acute undifferentiated leukemia. Additional markers CD303/ BDCA-2 and CD123 which are recently validated plasmacytoid dendritic cell markers were done which helped us clinch the diagnosis of this rare neoplasm. An accurate diagnosis of BPDCN is essential in order to provide prompt treatment. Due to its rarity and only recent recognition as a distinct clinicopathological entity, no standardized therapeutic approach has been established for BPDCN.en_US
dc.identifier.citationDharmani Preeti Ashok, Mittal Neha Manish, Subramanian P G, Galani Komal, Badrinath Yajamanam, Amare Pratibha, Gujral Sumeet. Blastic plasmacytoid dendritic cell neoplasm: Report of two pediatric cases. Indian journal of pathology& Microbiology 2015 Jan-Mar 58: (1) 72-76.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/156189
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2015;volume=58;issue=1;spage=72;epage=76;aulast=Dharmanien_US
dc.subjectBlastic plasmacytoid dendritic cell neoplasmen_US
dc.subjectCD123en_US
dc.subjectCD303en_US
dc.subjectBDCA-2en_US
dc.subjectpediatricen_US
dc.titleBlastic plasmacytoid dendritic cell neoplasm: Report of two pediatric cases.en_US
dc.typeArticleen_US
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