Application of response surface methodology as mathematical and statistical tools in natural product research

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dc.contributor.authorFlorentinus, Dika Octa Riswantoen_US
dc.contributor.authorAbdul, Rohmanen_US
dc.contributor.authorSuwidjiyo, Pramonoen_US
dc.contributor.authorSudibyo, Martonoen_US
dc.date.accessioned2020-10-16T08:55:46Z
dc.date.available2020-10-16T08:55:46Z
dc.date.issued2019-10
dc.description.abstractResponse Surface Methodology (RSM) models combined with experimental designs became popular in recentyears. Their advantages to analyze the interactive effects among different factors and the efficiency considerationsencouraged more researchers to conduct natural product research employed with these models. A review about basicprinciples of factorial designs, central composite designs, Box–Behnken designs, and Doehlert designs which utilizedalong with the RSM and their applications in natural product research is presented. The objective of this reviewwas to report various experimental design techniques and their applications in the field of natural product research.Furthermore, the characteristic of each design is also presented and the trends of RSM applications in natural productresearch are also discussed in this paper.en_US
dc.identifier.affiliationsDepartment of Pharmacy, Faculty of Pharmacy, Sanata Dharma University, Campus III Paingan, Maguwoharjo, Depok, Sleman,  Yogyakarta 55282 Indonesiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, 55281, Indonesia.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, 55281, Indonesiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, 55281, Indonesiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, 55281, Indonesiaen_US
dc.identifier.citationFlorentinus Dika Octa Riswanto, Abdul Rohman, Suwidjiyo Pramono, Sudibyo Martono. Application of response surface methodology as mathematical and statistical tools in natural product research. Journal of Applied Pharmaceutical Science. 2019 Oct; 2019 Oct: 125-133en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210475
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber10en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.91018en_US
dc.subjectBox–Behnken designen_US
dc.subjectcentral composite designen_US
dc.subjectDoehlert designen_US
dc.subjectfactorial designen_US
dc.subjectresponse surface methodology.en_US
dc.titleApplication of response surface methodology as mathematical and statistical tools in natural product researchen_US
dc.typeJournal Articleen_US
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