Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study

Simple item page
dc.contributor.authorS, VPen_US
dc.contributor.authorMunagala, Ken_US
dc.contributor.authorMood, Nen_US
dc.contributor.authorBaddam, GSC.en_US
dc.date.accessioned2023-06-27T06:38:17Z
dc.date.available2023-06-27T06:38:17Z
dc.date.issued2022-08
dc.description.abstractBackground: Otomycosis is a common condition of the external auditory canal. Aspergillus species and candida species are common causative agents for otomycosis. Clotrimazole is effective in controlling candida species than Aspergillus species. The povidone-iodine is a routinely used antiseptic solution in surgical care. Aims and Objectives: To assess the efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis. Materials and Methods: This prospective randomized study recruited 128 cases of both genders. The study participants were randomly divided into two groups. Group 1 received 7.5% povidone-iodine and group 2 received clotrimazole (1%). After removal of otomycotic debris, the study cases were randomly administered with study drugs three drops once a day. All the cases were strictly advised to adhere to the treatment procedure not <2 weeks. Descriptive statistics and Chi-square test was used to test the significance of qualitative data by SPSS 16.0. The P < 0.005 was considered as statistically significant. Results: After 14 days treatment, 1% clotrimazole group, showed continuous ear discharge (6.25%), pruritus (3.12%), tinnitus (3.12%), otalgia (1.56%), and deafness (1.56%), which was higher than 7.5% povidone-iodine group. Aspergillus niger (1 case) and Aspergillus flavus (2 cases) isolates were observed in 1% clotrimazole group. Good treatment response after the 5th day was seen in 15.62% and 18.75% cases, after the 9th day in 45.31% and 48.43%, and after the 14th day in 87.5% and 75% in 7.5% povidone-iodine and 1% clotrimazole groups, respectively. Conclusion: The cases treated with 7.5% povidone-iodine were showed comparatively less bacterial and fungal isolates and less clinical signs and symptoms than cases treated with 1% clotrimazole after 2 weeks of treatment follow-up.en_US
dc.identifier.affiliationsDepartment of ENT, ESIC Medical College, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonology, ESIC Medical College and Hospital, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of DVL, Kamineni Institute of Medical Sciences, Narketpally, Telangana, Indiaen_US
dc.identifier.citationS VP, Munagala K, Mood N, Baddam GSC.. Efficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized study. National Journal of Physiology, Pharmacy and Pharmacology. 2022 Aug; 12(8): 1142-1146en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217686
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber8en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2022.12.12451202124122021en_US
dc.subjectOtomycosisen_US
dc.subjectAnti-fungal Drugsen_US
dc.subjectEfficacyen_US
dc.subjectAspergillus Speciesen_US
dc.subjectCandida Speciesen_US
dc.titleEfficacy of 7.5% povidone-iodine and 1% clotrimazole in the treatment of otomycosis – A prospective randomized studyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
NJPPP2022v12n8p1142.pdf
Size:
245.17 KB
Format:
Adobe Portable Document Format
Download
Collections
National Journal of Physiology, Pharmacy and Pharmacology