Systemic Haemophilus influenzae disease in Thai children.

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dc.contributor.authorLikitnukul, Sen_US
dc.date.accessioned2009-05-27T15:29:07Z
dc.date.available2009-05-27T15:29:07Z
dc.date.issued1994-12-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractFifty patients with systemic Haemophilus influenzae disease were indentified by hospital chart review between 1980-1992. The age distribution varied from 8 days to 14 years; the mean age of the patients was 12.7 months. The peak incidence was between 4 and 6 months of age. There were 27 male patients and 23 female patients for a male:female ratio of 1.17:1. The relative frequencies of 79 clinical entities encountered in 50 patients are as follows: meningitis 55.7%, bacteremia 13.9%, pneumonia 25.3%, cellulitis 2.5% arthritis 1.3%, septic shock 1.3%. There were 23 patients (46%) who had more than one disease entity. Most of the patients were anemic (Hb < 10 gm%) when hospitalization. Sixty-four percent of the patients had early complications. The mortality rate was 8%. Although serotyping was not done from the isolates, at least 33 cerebrospinal fluid samples were positive for H. influenzae type b capsular antigen by counterimmunoelectrophoresis. The percentage of susceptible H. influenzae to penicillin, ampicillin, chloramphenicol, co-trimoxazole were 57.1%, 76.4%, 87.5% and 54.2%, respectively. There was no strain resistant to third generation cephalosporin. Our data indicate that H. influenzae is a serious and life threatening infection. Early diagnosis and proper treatment will reduce the morbidity and mortality rates. For prevention of infection, an appropriate strategy for vaccination is required.en_US
dc.description.affiliationDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationLikitnukul S. Systemic Haemophilus influenzae disease in Thai children. The Southeast Asian Journal of Tropical Medicine and Public Health. 1994 Dec; 25(4): 672-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32898
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshBacteremia --diagnosisen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHaemophilus Infections --diagnosisen_US
dc.subject.meshHaemophilus influenzaeen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshMeningitis, Haemophilus --diagnosisen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleSystemic Haemophilus influenzae disease in Thai children.en_US
dc.typeJournal Articleen_US
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