Prevalence of bancroftian filariasis on the Thai-Myanmar border.

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dc.contributor.authorNuchprayoon, Surangen_US
dc.contributor.authorSanprasert, Vivornpunen_US
dc.contributor.authorPorksakorn, Chantimaen_US
dc.contributor.authorNuchprayoon, Issarangen_US
dc.date.accessioned2009-05-27T17:22:15Z
dc.date.available2009-05-27T17:22:15Z
dc.date.issued2003-09-23en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractTo achieve the goal of eliminating lymphatic filariasis by the year 2020, close monitoring systems and effective control strategies need to be implemented and the real disease burden needs to be assessed. Bancroftian filariasis is endemic at the Thai-Myanmar border. However, there are only limited data on the prevalence of this disease in Thailand available. We employed microscopic examination, together with ELISA kits to detect W. bancrofti-specific Og4C3 circulating antigen and specific anti-filarial IgG4 antibodies to determine the burden of bancroftian filariasis in an endemic area at the Thai-Myanmar border in Umphang District, Tak province, Thailand. A total of 433 Thai-Karen blood samples were analyzed. The microfilarial rate determined by microscope was 6% and the W. bancrofti-specific Og4C3 antigenemia rate was 22%, while the specific anti-filarial IgG4 antibody rate was 54%. There were statistically significant higher levels of W. bancrofti-specific Og4C3 antigen in the microfilaremic-antigenemic group than in the amicrofilaremic-antigenemic group (unpaired Student's t-test; p < 0.001), similar to the specific anti-filarial IgG4 antibody results (unpaired Student's t-test; p < 0.001). A statistically significant correlation of moderate degree between the presence of W. bancrofti-specific Og4C3 antigen and of specific anti-filarial IgG4 antibody was found in the amicrofilaremic group (r = 0.474, p < 0.001), but not in the microfilaremic group (r = 0.291, p > 0.05). Our study revealed a very high prevalence of bancroftian filariasis in this endemic area and thus emphasized the importance of using highly sensitive and specific diagnostic tools to evaluate the true prevalence of the disease.en_US
dc.description.affiliationDepartment of Parasitology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.en_US
dc.identifier.citationNuchprayoon S, Sanprasert V, Porksakorn C, Nuchprayoon I. Prevalence of bancroftian filariasis on the Thai-Myanmar border. Asian Pacific Journal of Allergy and Immunology. 2003 Sep; 21(3): 179-88en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37044
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibody Specificity --immunologyen_US
dc.subject.meshAntigens, Helminth --analysisen_US
dc.subject.meshElephantiasis, Filarial --epidemiologyen_US
dc.subject.meshEmigration and Immigrationen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin G --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrofilaria --immunologyen_US
dc.subject.meshMyanmar --epidemiologyen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshStatistics as Topicen_US
dc.subject.meshThailand --epidemiologyen_US
dc.subject.meshWuchereria bancrofti --immunologyen_US
dc.titlePrevalence of bancroftian filariasis on the Thai-Myanmar border.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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