Relationship between soluble leptin receptor, leptin, lipid profiles and anthropometric parameters in overweight and obese Thai subjects.

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dc.contributor.authorPopruk, Supaluken_US
dc.contributor.authorTungtrongchitr, Rungsunnen_US
dc.contributor.authorPongpaew, Praneeten_US
dc.contributor.authorPhonrat, Benjalucken_US
dc.contributor.authorTungtrongchitr, Anchaleeen_US
dc.contributor.authorTribunyatkul, Siriwanen_US
dc.contributor.authorPaksanont, Supornen_US
dc.contributor.authorVudhivai, Niyomsrien_US
dc.contributor.authorSchelp, Frank Pen_US
dc.date.accessioned2009-05-27T21:29:19Z
dc.date.available2009-05-27T21:29:19Z
dc.date.issued2005-02-21en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractMedian, range and 95% confidence interval (CI) for median of age, anthropometric variables, soluble leptin receptor, serum leptin and lipid profile levels of 48 overweight (Body mass index (BMI) = 25.00-29.99 kg/m2) and obese (BMI > or = 30. 00 kg/m2) Thai males and 166 overweight and obese Thai females, compared with 26 males and 81 females in a control group (BMI = 18.50-24.99 kg/m2), were determined The study subjects were persons who turned up regularly for physical check-ups at the Out-patient Department, General Practice Section, Ratchawithi Hospital, Bangkok, aged between 18-60 years. Serum leptin, triglyceride and low density lipoprotein cholesterol/high density lipoprotein cholesterol ratios (LDL-C/ HDL-C ratio) were significantly higher in the overweight and obese males and females. Soluble leptin receptor and HDL-C were significantly lower in the overweight and obese males and females. Cholesterol and LDL-C were significantly higher in the overweight and obese females, but there was no significant difference in the overweight and obese males when compared with the control males. Low soluble leptin receptor levels were found in 38.1% (8/21) of the overweight and obese males, while 31.5% (29/92) were found in the overweight and obese females. Elevated leptin levels were found in 66.7% (32/48) and 89.8% (149/166) of the overweight and obese males and females, respectively. Both low soluble leptin receptor levels and elevated leptin levels were found in 9.5% (2/21) and 29.4% (27/92) of the overweight and obese males and females, respectively. A significant positive correlation was found between soluble leptin receptor and cholesterol, and between weight, BMI, waist, hip and HDL-C, with leptin. Serum soluble leptin receptor levels were significantly negatively correlated with leptin and BMI. The results can elucidate the causes and consequences of obesity, and are expected to aid the provision of care for overweight and obese Thai people.en_US
dc.description.affiliationDepartment of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Rd, Bangkok 10400, Thailand.en_US
dc.identifier.citationPopruk S, Tungtrongchitr R, Pongpaew P, Phonrat B, Tungtrongchitr A, Tribunyatkul S, Paksanont S, Vudhivai N, Schelp FP. Relationship between soluble leptin receptor, leptin, lipid profiles and anthropometric parameters in overweight and obese Thai subjects. Journal of the Medical Association of Thailand. 2005 Feb; 88(2): 220-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44878
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnthropometry --methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeptin --blooden_US
dc.subject.meshLipids --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshObesity --blooden_US
dc.subject.meshOvernutrition --blooden_US
dc.subject.meshReceptors, Cell Surface --blooden_US
dc.subject.meshReceptors, Leptinen_US
dc.titleRelationship between soluble leptin receptor, leptin, lipid profiles and anthropometric parameters in overweight and obese Thai subjects.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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