Existing challenges and histopathological review of borderline ovarian epithelial tumors

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dc.contributor.authorSingh, Ren_US
dc.contributor.authorRaman, Een_US
dc.contributor.authorAgarwal, Pen_US
dc.contributor.authorMaurya, MKen_US
dc.contributor.authorJaiswal, Ren_US
dc.contributor.authorGupta, Sen_US
dc.contributor.authorSolanki, Ven_US
dc.contributor.authorAgarwal, Sen_US
dc.contributor.authorSingh, AK.en_US
dc.date.accessioned2025-05-12T07:25:31Z
dc.date.available2025-05-12T07:25:31Z
dc.date.issued2024-10
dc.description.abstractBackground: The borderline tumour seen in the ovary can be with or without stromal invasion. Diagnosis and application of the correct criteria are of utmost importance to avoid over or undertreatment of these. We analyzed the borderline tumors reported in 2 years with respect to clinical outcome based on the morphological diagnosis and points that needed reconsideration. Methods: Cases reported as borderline tumors in ovary were retrieved from records reviewed and follow up was recorded. Additionally, we performed a morphometric analysis to confirm the maximum size of the invasive front. Results: A total of 467 resected ovarian tumor specimens were received, of which 266 (266/467 *100=56.9%) were epithelial tumors; out of them 54.88% were benign, 4.88% were borderline and 40.22% were malignant. The mean age at the time of borderline diagnosis was 38.66 years. On follow-up two cases among them developed further disease. One was reported from our center and one from outside, both were mucinous-type tumors. On critical review we found that there was minimal nuclear atypia in both, there was no evidence of convincing stromal invasion except few irregular well formed glands were seen infiltrating the stroma in one case. Conclusions: A large multicenter, interdisciplinary collaboration and data-driven study is needed to reconfirm and reconsider the cut-off of 5mm especially in mucinous tumors.en_US
dc.identifier.affiliationsDepartment of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, KGMU, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, KGMU, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, KGMU, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Surgical Oncology, King George's Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, KGMU, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, KGMU, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.citationSingh R, Raman E, Agarwal P, Maurya MK, Jaiswal R, Gupta S, Solanki V, Agarwal S, Singh AK.. Existing challenges and histopathological review of borderline ovarian epithelial tumors . International Journal of Research in Medical Sciences. 2024 Oct; 12(10): 3716-3720en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246852
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2320-6012.ijrms20242931en_US
dc.subjectOvaryen_US
dc.subjectMorphometryen_US
dc.subjectAdnexal tumorsen_US
dc.subjectMucinous adenocarcinomaen_US
dc.subjectSerous cystadenomaen_US
dc.titleExisting challenges and histopathological review of borderline ovarian epithelial tumorsen_US
dc.typeJournal Articleen_US
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