Retrospective analysis of role of interstitial brachytherapy using template (MUPIT) in locally advanced gynecological malignancies.

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dc.contributor.authorNandwani, Pooja Ken_US
dc.contributor.authorVyas, Rakesh Ken_US
dc.contributor.authorNeema, J Pen_US
dc.contributor.authorSuryanarayan, Unnikrishan Ken_US
dc.contributor.authorBhavsar, Devang Cen_US
dc.contributor.authorJani, Kinjal Ren_US
dc.date.accessioned2007-04-14en_US
dc.date.accessioned2009-06-01T16:20:40Z
dc.date.available2007-04-14en_US
dc.date.available2009-06-01T16:20:40Z
dc.date.issued2007-04-14en_US
dc.description.abstractAIM: The aim of this retrospective study was to assess treatment outcomes for patients with locally advanced gynecological malignancies being treated with interstitial brachytherapy using Martinez universal perineal interstitial template (MUPIT) and to study the acute and late sequelae and survival after treatment by this technique. MATERIALS AND METHODS: Ninety seven patients untreated with histopathological confirmation of carcinoma of cervix (37) vault (40) and vagina (20) were treated by combination of external beam RT (EBRT) using megavoltage irradiation to pelvis to dose of 4000-5000 cGy followed by interstitial brachytherapy using MUPIT between September 2001 to March 2005. Median age was 46 years. Only those patients who were found unsuitable for conventional brachytherapy or in whom intracavitatory radiotherapy was found to be unlikely to encompass a proper dose distribution were treated by interstitial template brachytherapy using MUPIT application and were enrolled in this study. The dose of MUPIT was 1600-2400 cGy in 4-6# with 400 cGy/# and two fractions a day with minimum gap of six hours in between two fractions on micro-HDR. Criteria for inclusion of patients were as follows: Hb minimum 10 gm/dl, performance status--70% or more (Karnofsy scale), histopathological confirmation FIGO stage IIB-IIIB (excluding frozen pelvis). RESULTS: Among the 97 patients studied, 12 patients lost to follow-up and hence they were excluded from the study. Follow-up of rest of the patients was then done up to September 2006. The duration of follow-up was in the range of 20-60 months. Parameters studied were local control rate, complication rate, mortality rate and number of patients developing systemic metastasis. Local control was achieved in 56/85 (64.7%) and complication rate was 15/85 (17.6%). Local control was better for nonbulky tumors compared bulky tumors irrespective of stage of disease. Local control was better in patients with good regression of disease after external beam radiotherapy. Time of gap between EBRT and implant also had an impact on the outcome. CONCLUSION: Interstitial template brachytherapy by MUPIT is a good alternative to deliver high dose radiation in locally advanced gynecological malignancies where conventional brachytherapy application is either not feasible or likely to give optimal dose distribution. Loco regional control obtained is definitely better than EBRT alone and within the accepted range of complications.en_US
dc.description.affiliationDepartment of Radiation Oncology, Gujarat Cancer and Research Institute, Ahmedabad, India. drpoojanandwanipatel@yahoo.co.inen_US
dc.identifier.citationNandwani PK, Vyas RK, Neema JP, Suryanarayan UK, Bhavsar DC, Jani KR. Retrospective analysis of role of interstitial brachytherapy using template (MUPIT) in locally advanced gynecological malignancies. Journal of Cancer Research and Therapeutics. 2007 Apr-Jun; 3(2): 111-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111483
dc.language.isoengen_US
dc.source.urihttps://www.cancerjournal.neten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshBrachytherapy --adverse effectsen_US
dc.subject.meshCarcinoma --radiotherapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGenital Neoplasms, Female --radiotherapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleRetrospective analysis of role of interstitial brachytherapy using template (MUPIT) in locally advanced gynecological malignancies.en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
dc.typeTechnical Reporten_US
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