Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial.

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dc.contributor.authorTilwe, G Hen_US
dc.contributor.authorBeria, Sen_US
dc.contributor.authorTurakhia, N Hen_US
dc.contributor.authorDaftary, G Ven_US
dc.contributor.authorSchiess, Wen_US
dc.date.accessioned2001-06-05en_US
dc.date.accessioned2009-05-31T01:42:02Z
dc.date.available2001-06-05en_US
dc.date.available2009-05-31T01:42:02Z
dc.date.issued2001-06-05en_US
dc.description.abstractOBJECTIVE: To compare the efficacy and tolerability of an oral enzyme preparation (Phlogenzym) with that of an NSAID (diclofenac) in the treatment of active osteoarthrosis. METHODS: Prospective, randomized, controlled, single-blind study of seven weeks duration at a tertiary care centre wherein 50 patients aged 40-75 years, with activated osteoarthrosis of knee joint were randomized to receive phlogenzym tablets (2-3 tablets, bid) or diclofenac sodium 50 mg bid for three weeks. RESULTS: At the end of therapy (three weeks) and at follow-up visit at seven weeks there was reduction in pain and joint tenderness and swelling in both groups, and slight improvement in the range of movement in the study group. The reduction in joint tenderness was greater (p < 0.05) in the study group receiving phlogenzym. CONCLUSION: Phlogenzym is as efficacious and well tolerated as diclofenac sodium in the management of active osteoarthrosis over three weeks of treatment.en_US
dc.description.affiliationDepartment of Medicine, GS Medical College and KEM Hospital, Mumbai.en_US
dc.identifier.citationTilwe GH, Beria S, Turakhia NH, Daftary GV, Schiess W. Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial. Journal of the Association of Physicians of India. 2001 Jun; 49(): 617-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/92400
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --therapeutic useen_US
dc.subject.meshBromelains --therapeutic useen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshDiclofenac --therapeutic useen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunologic Factors --therapeutic useen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteoarthritis, Knee --drug therapyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRutin --analogs & derivativesen_US
dc.subject.meshSingle-Blind Methoden_US
dc.subject.meshTrypsin --therapeutic useen_US
dc.titleEfficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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