Concurrent chemoradiation in head and neck cancers with weekly cisplatin: analysing toxicities

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dc.contributor.authorVias, Poorvaen_US
dc.contributor.authorGupta, Manojen_US
dc.contributor.authorSeam, Rajeev Kumaren_US
dc.contributor.authorGupta, Manishen_US
dc.contributor.authorFotedar, Vikasen_US
dc.contributor.authorAhuja, Rachiten_US
dc.date.accessioned2020-11-18T10:00:02Z
dc.date.available2020-11-18T10:00:02Z
dc.date.issued2019-12
dc.description.abstractBackground: Head and neck cancers constitute 6% of cancers worldwide. The management requires a multidisciplinary approach. Concomitant chemoradiotherapy with cisplatin is the standard approach for locally advanced head and neck cancers. The most commonly used regime uses three weekly cisplatin which is more toxic. Low-dose once-a-week cisplatin is substituted because of perceived lower toxicity and convenience.  Methods: Squamous cell carcinoma of stage III, IVA and IVB of oropharynx, hypopharynx and larynx were studied for one year. 82 patients were studied. Total dose of radiation was 66Gy/33#/6 ½ weeks from Monday to Friday with inj. Cisplatin 40mg/m2 i.v. infusion weekly.Results: 88% of patients were able to complete five or more weekly chemotherapy cycles with cumulative dose of 200mg/m2. Grade 2 and 3 acute toxicities were seen in weekly cisplatin arm but were conservatively managed.Conclusions: Weekly cisplatin can be used with concurrent radiotherapy as the acute toxicities are manageable and is well tolerated.en_US
dc.identifier.affiliationsDepartment of Radiation Oncology, IGMC, Shimla, Himachal Pradesh, Indiaen_US
dc.identifier.citationVias Poorva, Gupta Manoj, Seam Rajeev Kumar, Gupta Manish, Fotedar Vikas, Ahuja Rachit. Concurrent chemoradiation in head and neck cancers with weekly cisplatin: analysing toxicities. International Journal of Research in Medical Sciences. 2019 Dec; 7(12): 4748-4752en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211796
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber12en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20195515en_US
dc.subjectCisplatin, toxicities, Concurrent chemoradiotherapy, Head and Neck cancer, Squamous cell carcinomaen_US
dc.titleConcurrent chemoradiation in head and neck cancers with weekly cisplatin: analysing toxicitiesen_US
dc.typeJournal Articleen_US
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