Salivary cortisol in the assessment of adrenocortical function in patients with pulmonary tuberculosis.

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dc.contributor.authorImmanuel, Cen_US
dc.contributor.authorSarma, G Ren_US
dc.contributor.authorKrishnamurthy, P Ven_US
dc.contributor.authorRamachandran, Gen_US
dc.contributor.authorKumaraswami, Ven_US
dc.date.accessioned1992-01-01en_US
dc.date.accessioned2009-05-27T07:23:26Z
dc.date.available1992-01-01en_US
dc.date.available2009-05-27T07:23:26Z
dc.date.issued1992-01-01en_US
dc.description.abstractAdrenocortical function was assessed on the basis of changes in salivary cortisol in patients with pulmonary tuberculosis and the findings compared with those in healthy subjects. A method of direct radioimmunoassay of salivary cortisol was standardized and the sensitivity was 0.8 nmol/l. Cortisol levels in saliva were significantly higher in the patients than in the healthy subjects (P less than 0.001). The diurnal rhythm of cortisol secretion was disturbed in the patients with a significant increase in salivary cortisol beyond 1800 h. While dexamethasone caused an appreciable suppression (87%), stimulation with ACTH (tetracosactrin) resulted in a marked increase in salivary cortisol, the increase being significantly higher in the healthy subjects than in the patients (P less than 0.001). Attempts to classify subjects as positive or negative responders to tetracosactrin based on increases in salivary cortisol in relation to plasma cortisol changes were however not successful, as the agreement between the two methods ranged from 73 to 80 per cent with various criteria used.en_US
dc.description.affiliationTuberculosis Research Centre, Madras.en_US
dc.identifier.citationImmanuel C, Sarma GR, Krishnamurthy PV, Ramachandran G, Kumaraswami V. Salivary cortisol in the assessment of adrenocortical function in patients with pulmonary tuberculosis. Indian Journal of Medical Research. 1992 Jan; 95(): 1-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/20510
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdrenal Cortex --physiopathologyen_US
dc.subject.meshAdrenal Cortex Function Tests --methodsen_US
dc.subject.meshCircadian Rhythmen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrocortisone --analysisen_US
dc.subject.meshSaliva --chemistryen_US
dc.subject.meshTuberculosis, Pulmonary --physiopathologyen_US
dc.titleSalivary cortisol in the assessment of adrenocortical function in patients with pulmonary tuberculosis.en_US
dc.typeJournal Articleen_US
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