Efficacy and safety of tadalafil in ureteric stent related symptoms: a double blind, prospective, randomised study

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dc.contributor.authorChauhan, Vinod K.en_US
dc.contributor.authorSingla, Manish K.en_US
dc.contributor.authorDumra, Anujen_US
dc.contributor.authorAgarwal, Nitinen_US
dc.contributor.authorBawa, Amarpreet S.en_US
dc.date.accessioned2020-11-18T09:58:28Z
dc.date.available2020-11-18T09:58:28Z
dc.date.issued2019-05
dc.description.abstractBackground: Is tadalafil effective and safe in ureteric stent related symptoms? The objective of this trial is to study the efficacy and safety of tadalafil and compare it with tamsulosin in relieving ureteric stent related symptoms by using ureteral stent symptom questionnaire.Methods: Total 144 patients with dj stent symptoms were randomized into two groups with 72 patients in each. Group A patients were given tadalafil 5mg and Group B, tamsulosin 0.4mg for 2 weeks. Ureteral stent symptom questionnaire was filled on 7th day and on 21st day after stent insertion. Statistically significant difference between groups was determined by the t-test, Mann-Whitney U-test, Pearson Chi-square test or Fisher's exact test. Comparison between quantitative time related variables was done by Wilcoxon Signed Rank test. All the statistical tests were two-sided and were performed at a significance level of α=.05.Results: Tamsulosin was found more effective then tadalafil in decreasing mean urinary index (p=0.004). Tadalafil caused significant decrease in body pain (p=0.006) and improvement in general health index score, work performance and sex score (P value= 0.041, <0.001 and <0.015 respectively) as compared to tamsulosin. Additional problems score improvement and analgesic use were found comparable in 2 groups (p value =0.193, 0.070 respectively). Adverse effect with both the drugs were minimal, mild to moderate and self-limiting.Conclusions: Tadalafil found more effective then Tamsulosin in relieving body pain, sexual symptoms and improving general health and work performance but less effective in improvement of urinary symptoms.en_US
dc.identifier.affiliationsDepartment of Urology, Fortis Hospital, Mohali, Punjab, Indiaen_US
dc.identifier.affiliationsDepartment of Urology, Sri Sathya Sai Institute of Higher Medical Sciences, Puttaparthi, Andhra Pradesh, Indiaen_US
dc.identifier.citationChauhan Vinod K., Singla Manish K., Dumra Anuj, Agarwal Nitin, Bawa Amarpreet S.. Efficacy and safety of tadalafil in ureteric stent related symptoms: a double blind, prospective, randomised study. International Journal of Research in Medical Sciences. 2019 May; 7(5): 1472-1478en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211356
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20191523en_US
dc.subjectTadalafilen_US
dc.subjectTamsulosinen_US
dc.subjectUreteral stent symptom questionnaireen_US
dc.titleEfficacy and safety of tadalafil in ureteric stent related symptoms: a double blind, prospective, randomised studyen_US
dc.typeJournal Articleen_US
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