Incidence of infections in patients with pemphigus vulgaris

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dc.contributor.authorNarain, Upmaen_US
dc.contributor.authorKant, Tejasen_US
dc.contributor.authorKant, Arunen_US
dc.date.accessioned2023-08-28T06:36:00Z
dc.date.available2023-08-28T06:36:00Z
dc.date.issued2022-06
dc.description.abstractBackground:Pemphigus is a rare, chronic autoimmune blistering disease of skin and mucous membranes. Autoimmune process and immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. Therefore, the objective of this study was to isolate and identify the pathogens in admitted patients suffering from pemphigus vulgaris.Methods:This was a retrospective observational study based on 68 diagnosed cases of pemphigus vulgaris (PV) admitted during January1999 to April 2018 in SRN hospital, MLN medical college Prayagraj. Patients who had PV and required admission owing to development of severe symptoms were included while patients with mild symptoms were excluded from the study. These admitted patients, along with routine and radiological examination, were also examined for microbiological examinations of sputum, throat swab, blood, body fluids, skin scrapings, stool and urine when necessary.Results:Out of the 68 patients, 66.17% patients developed bacterial infections while 33.83% developed fungal infections. The prevalence of bacterial and fungal pathogens in urinary tract is 72.42% and 27.58%, pneumonitis is 29.42% and 70.58%, septicaemia is 81.82% and 18.18% and skin and soft tissue is 87.50% and 12.50% respectively. In meningitis and pulmonary tuberculosis no traces of fungi were recorded. Mortality was seen in 7.35% patients, which wasdue to bacterial meningitis, septicaemia and fungal pneumonitis.Conclusions:The present study clearly states that the occurrence of the disease is uncommon but secondary infections are associated with worse prognosis. Therefore, the best regimen for each type of patients should base on the extent of disease and patient’s comorbidities.en_US
dc.identifier.affiliationsDepartment of Microbiology, Tejas Microdiagnostic, Allahabad, Uttar Pradesh,Indiaen_US
dc.identifier.affiliationsSri Ramachandra Institute of Higher Education and Research No.1 Ramachandra Nagar, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Dermatology Tejas Clinic, Allahabad, Uttar Pradesh, Indiaen_US
dc.identifier.citationNarain Upma, Kant Tejas, Kant Arun. Incidence of infections in patients with pemphigus vulgaris. International Journal of Advances in Medicine. 2022 Jun; 9(6): 666-669en_US
dc.identifier.issn2349-3933
dc.identifier.issn2349-3925
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225816
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20221348en_US
dc.subjectInfectionen_US
dc.subjectPemphigus vulgarisen_US
dc.subjectAutoimmuneen_US
dc.subjectBacterialen_US
dc.subjectFungalen_US
dc.titleIncidence of infections in patients with pemphigus vulgarisen_US
dc.typeJournal Articleen_US
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