Discovered on gastrointestinal stromal tumor 1, a keystone in the diagnosis of extraintestinal gastrointestinal stromal tumors

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dc.contributor.authorSahu, Kausalya Kumarien_US
dc.contributor.authorTapadia, Rohiten_US
dc.contributor.authorKini, Jyoti Ramanathen_US
dc.contributor.authorPai, Radha Ren_US
dc.contributor.authorKini, Hemaen_US
dc.contributor.authorNirupama, Men_US
dc.contributor.authorPooja, KSen_US
dc.date.accessioned2020-11-18T10:07:31Z
dc.date.available2020-11-18T10:07:31Z
dc.date.issued2019-01
dc.description.abstractIntroduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract (GIT) but have a low incidence. Arising from the interstitial cells of Cajal, GISTs occur at different sites in the GIT with stomach being the most common. They can rarely be seen at sites outside the GIT such as omentum, retroperitoneum and are called as extraintestinal GISTs (EGIST). They have a spindle or epithelioid cell morphology and show positivity by immunohistochemistry (IHC) for CD117. Our aim was to study the clinicopathological and immunohistochemical profile of our cases of EGISTs. Materials and Methods: A cross-sectional study of EGISTs received from 2010 to 2015 was done. IHC with CD117 and discovered on GIST1 (DOG1) was performed and tumors were scored based on the percentage of cells that stained positive. Thirteen abdominal non-GIST spindle cell tumors were included in the study as controls. Results: Seven cases of EGIST were included (four-omental, three-retroperitoneal). All cases stained positive for CD117 and DOG1. One case of epithelioid EGIST scored 4 + with DOG1 and 2 + with CD117. Another case with mixed morphology scored 2 + with DOG1 and 4 + with CD117. All controls were negative for both markers. Conclusion: EGISTs are one of the rare differentials for spindle cell lesions outside the GIT. Although both markers stain positive, DOG1 showed higher score with epithelioid GISTsen_US
dc.identifier.affiliationsDepartment of Pathology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, Indiaen_US
dc.identifier.citationSahu Kausalya Kumari, Tapadia Rohit, Kini Jyoti Ramanath, Pai Radha R, Kini Hema, Nirupama M, Pooja KS. Discovered on gastrointestinal stromal tumor 1, a keystone in the diagnosis of extraintestinal gastrointestinal stromal tumors. Journal of Cancer Research and Therapeutics. 2019 Jan; 15(1): 138-141en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213544
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_28_17en_US
dc.subjectCD117en_US
dc.subjectdiscovered on gastrointestinal stromal tumor 1en_US
dc.subjectextraintestinal gastrointestinal stromal tumoren_US
dc.subjectimmunohistochemistryen_US
dc.titleDiscovered on gastrointestinal stromal tumor 1, a keystone in the diagnosis of extraintestinal gastrointestinal stromal tumorsen_US
dc.typeJournal Articleen_US
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