Preoperative and postoperative study of left ventricular function, hemodynamics and plasma catecholamine concentrations during dynamic exercise in patients with chronic mitral regurgitation.

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dc.contributor.authorHaque, E Uen_US
dc.contributor.authorSuyama, Aen_US
dc.contributor.authorMori, Ten_US
dc.date.accessioned1994-01-01en_US
dc.date.accessioned2009-05-27T04:21:17Z
dc.date.available1994-01-01en_US
dc.date.available2009-05-27T04:21:17Z
dc.date.issued1994-01-01en_US
dc.description.abstractWe studied 7 patients before and after mitral valve replacement (MVR) for chronic mitral regurgitation (MR) and 5 control subjects by echocardiography and right heart catheterization to assess left ventricular function, hemodynamics and plasma catecholamine concentrations during supine bicycle exercise. Left ventricular (LV) end-systolic dimension decreased and LV systolic function increased significantly during exercise in patients and control subjects. LV systolic function (fractional shortening and mean velocity of circumferential fiber shortening) was significantly lower in patients after MVR than before MVR (p < 0.05). Cardiac index at peak exercise was significantly higher in patients after MVR than before MVR (p < 0.05). Significantly greater augmentation in plasma norepinephrine (NE) levels were observed during exercise in patients both before and after MVR than in control subjects (p < 0.05). No significant differences in mean pulmonary artery pressure (PAP) and pulmonary capillary wedge pressure (PCWP) were observed between the patients before and after MVR. Thus, it is concluded that LV systolic and pump function (CI) during exercise were augmented by a compensatory activation of sympathetic nervous system in patients both before and after MVR for chronic MR.en_US
dc.description.affiliationCardiovascular Division, Tottori University School of Medicine, Yonago, Japan.en_US
dc.identifier.citationHaque EU, Suyama A, Mori T. Preoperative and postoperative study of left ventricular function, hemodynamics and plasma catecholamine concentrations during dynamic exercise in patients with chronic mitral regurgitation. Indian Heart Journal. 1994 Jan-Feb; 46(1): 11-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/3983
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshEpinephrine --blooden_US
dc.subject.meshExercise Testen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemodynamicsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMitral Valve Insufficiency --blooden_US
dc.subject.meshNorepinephrine --blooden_US
dc.subject.meshVentricular Function, Leften_US
dc.titlePreoperative and postoperative study of left ventricular function, hemodynamics and plasma catecholamine concentrations during dynamic exercise in patients with chronic mitral regurgitation.en_US
dc.typeJournal Articleen_US
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