Correlation of total and specific serum immunoglobulin E levels with the severity of chronic sinusitis in children.

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dc.contributor.authorLin, Y Len_US
dc.contributor.authorHuang, J Len_US
dc.contributor.authorChen, L Cen_US
dc.contributor.authorWang, C Ren_US
dc.date.accessioned2009-05-27T17:10:49Z
dc.date.available2009-05-27T17:10:49Z
dc.date.issued2001-03-10en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractChronic sinusitis is frequently associated with allergy and asthma. Previous studies have shown that serum immunoglobulin E (IgE) levels correlate with allergy and asthma in adults. Because the role of allergic inflammation in the severity of chronic sinusitis remains controversial in children, we set out to determine whether a correlation exists between serum levels of total and specific IgE and the severity of chronic sinusitis in children. Forty-four children with chronic sinusitis were enrolled in the study. Computed tomographic scans were reviewed and scored for the severity of sinusitis. All children were mite-sensitive. Serum samples were assayed for total IgE and specific IgE antibodies to mite allergen using a fluoroimmunoassay. Fourteen subjects had extensive sinus disease. There was no significant difference in the average of total and specific IgE between the subjects with extensive and limited disease (p = 0.562 and 0.755, respectively). Thirty-four subjects were diagnosed with asthma. The subjects with extensive sinus disease had a higher prevalence of moderate to severe asthma than the subjects with limited disease (p = 0.006), but there was no significant difference in the average of total and specific IgE between the subjects with different severities of asthma. (p = 0.833 and 0.425, respectively). The data suggests that levels of total or specific IgE do not correlate with severity of chronic sinusitis in children. Nonetheless, the severity of chronic sinusitis and asthma correlate well with each other irrespective of total and specific IgE.en_US
dc.description.affiliationDepartment of Pediatrics, Chang Gung Children's Hospital and Chang Gung University, Taoyuan, Taiwan.en_US
dc.identifier.citationLin YL, Huang JL, Chen LC, Wang CR. Correlation of total and specific serum immunoglobulin E levels with the severity of chronic sinusitis in children. Asian Pacific Journal of Allergy and Immunology. 2001 Mar; 19(1): 1-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36626
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAntibody Specificity --immunologyen_US
dc.subject.meshBlood Proteins --analysisen_US
dc.subject.meshChilden_US
dc.subject.meshChild Welfareen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshEosinophil Granule Proteinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin E --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRibonucleasesen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSinusitis --blooden_US
dc.subject.meshStatistics as Topicen_US
dc.subject.meshTaiwan --epidemiologyen_US
dc.titleCorrelation of total and specific serum immunoglobulin E levels with the severity of chronic sinusitis in children.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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