Clinico-pathological impact of cytogenetic subgroups in B-cell chronic lymphocytic leukemia: Experience from India.

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dc.contributor.authorKadam, Amare P S
dc.contributor.authorGadage, V
dc.contributor.authorJain, H
dc.contributor.authorNikalje, S
dc.contributor.authorManju, S
dc.contributor.authorMittal, N
dc.contributor.authorGujral, S
dc.contributor.authorNair, R
dc.date.accessioned2013-10-04T11:02:18Z
dc.date.available2013-10-04T11:02:18Z
dc.date.issued2013-07
dc.description.abstractBACKGROUND: The present study of 238 B‑cell Chronic Lymphocytic Leukemia (B‑CLL) patients were undertaken to seek the prevalence and to evaluate clinico‑pathological significance of recurrent genetic abnormalities such as del(13q14.3), trisomy 12, del(11q22.3) (ATM), TP53 deletion, del(6q21) and IgH translocation/deletion. MATERIALS AND METHODS: We applied interphase – fluorescence in situ hybridization (FISH) on total 238 cases of B‑CLL. RESULTS: Our study disclosed 69% of patients with genetic aberrations such as 13q deletion (63%), trisomy 12 (28%), 11q deletion (18%), 6q21 deletion (11%) with comparatively higher frequency of TP53 deletion (22%). Deletion 13q displayed as a most frequent sole abnormality. In group with coexistence of ≥2 aberrations, 13q deletion was a major clone indicating del(13q) as a primary event followed by 11q deletion, TP53 deletion, trisomy 12, 6q deletion as secondary progressive events. In comparison with del(13q), trisomy 12, group with coexistence of ≥2 aberrations associated with poor risk factors such as hyperleukocytosis, advanced stage, and multiple nodes involvement. In a separate study of 116 patients, analysis of IgH abnormalities revealed either partial deletion (24%) or translocation (5%) and were associated with del(13q), trisomy 12, TP53 and ATM deletion. Two of 7 cases had t(14;18), one case had t(8;14), and four cases had other variant IgH translocation t(?;14). CONCLUSION: Detail characterization and clinical impact are necessary to ensure that IgH translocation positive CLL is a distinct pathological entity. Our data suggests that CLL with various cytogenetic subsets, group with coexistence of ≥2 aberrations seems to be a complex cytogenetic subset, needs more attention to understand biological significance and to seek clinical impact for better management of disease.en_US
dc.identifier.citationKadam Amare P S, Gadage V, Jain H, Nikalje S, Manju S, Mittal N, Gujral S, Nair R. Clinico-pathological impact of cytogenetic subgroups in B-cell chronic lymphocytic leukemia: Experience from India. Indian Journal of Cancer. 2013 July-Sept; 50(3): 261-267.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/148659
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2013;volume=50;issue=3;spage=261;epage=267;aulast=Amareen_US
dc.subjectB‑cell chronic lymphocytic leukemiaen_US
dc.subjectfluorescence in situ hybridizationen_US
dc.subjectgroup with coexistence of ≥2 aberrationsen_US
dc.subjectIgH aberrationsen_US
dc.subjectclinical impacten_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshChromosome Aberrations
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshIndia
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell --genetics
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell --pathology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshYoung Adult
dc.titleClinico-pathological impact of cytogenetic subgroups in B-cell chronic lymphocytic leukemia: Experience from India.en_US
dc.typeArticleen_US
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