Biological agents in rheumatoid arthritis.

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dc.contributor.authorShankar, Sen_US
dc.contributor.authorHanda, Ren_US
dc.date.accessioned2004-10-30en_US
dc.date.accessioned2009-06-02T12:19:33Z
dc.date.available2004-10-30en_US
dc.date.available2009-06-02T12:19:33Z
dc.date.issued2004-10-30en_US
dc.description79 references.en_US
dc.description.abstractRheumatoid arthritis (RA) is the commonest inflammatory joint disease with considerable morbidity and mortality. Conventional disease-modifying antirheumatic drugs like methotrexate form the cornerstone of therapy. However, they have several limitations in terms of slow onset of action, adverse effects and modest remission and retention rates. Several cytokines are involved in the pathogenesis of RA. Biological agents that specifically inhibit the effects of tumour necrosis factor-a (TNF-a) or Interleukin-1 (IL-1) represent a major advancement in the treatment of RA. By targeting molecules that are directly involved in the pathogenesis of RA, these therapies are proving to be efficacious, highly specific and better tolerated than standard therapies. The use of these agents needs to be monitored carefully for possible side-effects, including the development of infections. Additional anti-cytokine agents for the treatment of RA are under further development.en_US
dc.description.affiliationDepartment of Medicine, Rheumatology service, All India Institute of Medical Sciences, New Delhi-110029, India. rohinihanda@hotmail.comen_US
dc.identifier.citationShankar S, Handa R. Biological agents in rheumatoid arthritis. Journal of Postgraduate Medicine. 2004 Oct-Dec; 50(4): 293-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/116829
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAntirheumatic Agents --pharmacologyen_US
dc.subject.meshArthritis, Rheumatoid --drug therapyen_US
dc.subject.meshCytokines --antagonists & inhibitorsen_US
dc.subject.meshHumansen_US
dc.titleBiological agents in rheumatoid arthritis.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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