Salmonella krefeld in Thailand: II. Molecular biology of drug resistance.

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dc.contributor.authorJayanetra, Pen_US
dc.contributor.authorVorachit, Men_US
dc.contributor.authorPilantanapak, Aen_US
dc.contributor.authorPanbangred, Wen_US
dc.contributor.authorBangtragulnonth, Aen_US
dc.contributor.authorChiewsilp, Den_US
dc.date.accessioned2009-05-27T16:50:42Z
dc.date.available2009-05-27T16:50:42Z
dc.date.issued1990-09-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractHuman salmonellosis due to Salmonella krefeld is very rare. During 1976-1978, a large outbreak of S. krefeld gastroenteritis occurred in Thailand, mainly in children. The majority of strains were multiply drug resistant with high minimum inhibitory concentration (MIC). The MIC for these drugs were ampicillin (Ap) 256-4096 mg/l, chloramphenicol (Cm) 256-512 mg/l, kanamycin (Km) 512- greater than 4096 mg/l, streptomycin (Sm) greater than 1024 mg/l, sulfamethoxazole (Su) 4096- greater than 8192 mg/l, tetracycline (Tc) 64-128 mg/l and trimethoprim (Tp) 64-256 mg/l. Resistance to Su and Tp declined after the period of the epidemic. The resistance genes were found to be highly transferable at a rate of 10(-2) to 10(-4). All strains with more than five resistance markers had large molecular weight plasmids of 120-140 megadaltons. The restriction profile analysis of plasmids from isolates collected from various regions of the country showed similarity of DNA fragment pattern. These isolates were resistant to Ap, Cm, Km, Sm, Su and Tc.en_US
dc.description.affiliationDepartment of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.en_US
dc.identifier.citationJayanetra P, Vorachit M, Pilantanapak A, Panbangred W, Bangtragulnonth A, Chiewsilp D. Salmonella krefeld in Thailand: II. Molecular biology of drug resistance. The Southeast Asian Journal of Tropical Medicine and Public Health. 1990 Sep; 21(3): 361-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36139
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshChilden_US
dc.subject.meshDNA, Bacterial --geneticsen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshHumansen_US
dc.subject.meshPlasmids --geneticsen_US
dc.subject.meshRestriction Mappingen_US
dc.subject.meshSalmonella --geneticsen_US
dc.subject.meshSalmonella Infections --drug therapyen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleSalmonella krefeld in Thailand: II. Molecular biology of drug resistance.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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