Pattern of drug-resistance and treatment outcome in multidrug-resistant pulmonary tuberculosis.

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dc.contributor.authorNagaraja, C
dc.contributor.authorShashibhushan, B L
dc.contributor.authorAsif, Mohamed
dc.contributor.authorManjunath, P H
dc.contributor.authorSagar, C
dc.date.accessioned2012-05-29T04:16:02Z
dc.date.available2012-05-29T04:16:02Z
dc.date.issued2012-01
dc.description.abstractAims and Objectives. To study the pattern of drug-resistance and treatment outcomes among patients with confirmed multidrug-resistant pulmonary tuberculosis (MDR-PTB). Methods. A prospective study was conducted at Rajiv Gandhi Institute of Chest Diseases, Bengaluru, Karnataka, India. Between January 2005 and December 2008, 224 confirmed MDR-PTB cases were studied for various drug-resistance patterns, and their treatment outcomes were analysed until November 2010. Sputum culture and drug sensitivity tests (DST) were carried out at National Tuberculosis Institute, Bengaluru; DST was done for all first-line drugs except pyrazinamide. Results. Of the 224 MDR-PTB patients, 146 (65.2%) were resistant to all first-line drugs, 39 (17.4%) to isoniazid, rifampicin and streptomycin; 19 (8.5%) to isoniazid, rifampicin and ethambutol; and 20 (8.9%) to isoniazid and rifampicin. Among them, 145 (64.7%) patients were cured, 5 (2.2%) had treatment-failure, 10 (4.4%) died, and 64 (28.5%) defaulted. Among 145 cured cases, 100 (69%) were resistant to all first-line drugs, 23 (16%) to isoniazid, rifampicin and streptomycin, 11(8%) to isoniazid, rifampicin and ethambutol, and 11(8%) to isoniazid and rifampicin. Conclusions. The most common pattern observed in this study was resistance to all four first-line drugs followed by resistance to isoniazid, rifampicin and streptomycin. Patients resistant to all first-line drugs had early sputum culture conversion and better cure rate as compared to other resistance patterns.en_US
dc.identifier.citationNagaraja C, Shashibhushan B L, Asif Mohamed, Manjunath P H, Sagar C. Pattern of drug-resistance and treatment outcome in multidrug-resistant pulmonary tuberculosis. The Indian Journal of Chest Diseases and Allied Sciences, 2012 Jan; 54(1): 23-26.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138691
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/iae/t12/i1/iaet12i1p23.pdfen_US
dc.subjectMDR-TBen_US
dc.subjectDrug resistanceen_US
dc.subjectTreatment outcomeen_US
dc.subject.meshAntitubercular Agents --pharmacology
dc.subject.meshAntitubercular Agents --therapeutic use
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMycobacterium tuberculosis --drug effects
dc.subject.meshTreatment Outcome
dc.subject.meshTuberculosis, Multidrug-Resistant --drug therapy
dc.subject.meshTuberculosis, Pulmonary --drug therapy
dc.titlePattern of drug-resistance and treatment outcome in multidrug-resistant pulmonary tuberculosis.en_US
dc.typeArticleen_US
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