Clinical Profile of Critical Pertussis in Children at a Pediatric Intensive Care Unit in Northern India

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dc.contributor.authorKavitha, TKen_US
dc.contributor.authorSamprathi, Madhusudanen_US
dc.contributor.authorJayashree, Muralidharanen_US
dc.contributor.authorGautam, Vikasen_US
dc.contributor.authorSangal, Luckyen_US
dc.date.accessioned2020-04-23T07:45:04Z
dc.date.available2020-04-23T07:45:04Z
dc.date.issued2020-03
dc.description.abstractObjective: To delineate the clinical profile, complications, intensive care needs, andpredictors of mortality in children with critical pertussis. Methods: Retrospective analysis ofcase records of children in the pediatric intensive care unit of a tertiary-care hospital, with adiagnosis of critical pertussis over 3 years. Diagnostic criteria included CDC case definitionand confirmation by polymerase chain reaction (PCR), when available. Survivors and non-survivors were compared to identify predictors of mortality. Results: 36 records wereanalysed, most cases were infants (31, 86.1%). 10 (27.7%) were (below 6 weeks of age). Inthe rest, 16 (61.5%) were partially immunized or unimmunized against pertussis. Rapidbreathing (88.9%), paroxysmal cough (86.1%) and apnea (41.7%) were common presentingcomplaints. Hypoxemia (97.2%), hyperleukocytosis (61.1%) and encephalopathy (52.8%)were common complications. Intensive care needs were mechanical ventilation in 11(30.6%), vasoactive support in 7 (19.4%) and exchange transfusion in 3 (8.3%). Femalegender, apnea, hyperleukocytosis, encephalopathy, need for vasoactive support, andmechanical ventilation predicted mortality. Conclusion: Pertussis demands attention due toits varied presentation, increased complications and higher mortality.en_US
dc.identifier.affiliationsPediatric Emergency and Intensive Care Units, Institute of Medical Education andResearch, Chandigarh, Indiaen_US
dc.identifier.affiliationsMedical Microbiology, Post Graduate Institute of Medical Education andResearch, Chandigarh, Indiaen_US
dc.identifier.affiliationsNPO-VPD laboratories, WHO Country Office for India.en_US
dc.identifier.citationKavitha TK, Samprathi Madhusudan, Jayashree Muralidharan, Gautam Vikas, Sangal Lucky. Clinical Profile of Critical Pertussis in Children at a Pediatric Intensive Care Unit in Northern India. Indian Pediatrics. 2020 Mar; 57(3): 228-231en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199502
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber3en_US
dc.relation.volume57en_US
dc.source.urihttps://www.indianpediatrics.net/mar2020/228.pdfen_US
dc.subjectApneaen_US
dc.subjectDPT vaccineen_US
dc.subjectImmunizationen_US
dc.subjectOutcomeen_US
dc.titleClinical Profile of Critical Pertussis in Children at a Pediatric Intensive Care Unit in Northern Indiaen_US
dc.typeJournal Articleen_US
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