Pharmacological effects of Withania somnifera root extract on GABAA receptor complex.

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dc.contributor.authorMehta, A Ken_US
dc.contributor.authorBinkley, Pen_US
dc.contributor.authorGandhi, S Sen_US
dc.contributor.authorTicku, M Ken_US
dc.date.accessioned1991-08-01en_US
dc.date.accessioned2009-05-27T06:56:27Z
dc.date.available1991-08-01en_US
dc.date.available2009-05-27T06:56:27Z
dc.date.issued1991-08-01en_US
dc.description.abstractA methanolic extract of W. somnifera root inhibited the specific binding of [3H]GABA and [35S]TBPS, and enhanced the binding of [3H]flunitrazepam to their putative receptor sites. The extract (5 micrograms) inhibited [3H]GABA binding by 20 +/- 6 per cent whereas a concentration of 1 mg of the extract produced 100 per cent inhibition. The extract (5-100 micrograms) produced 20 +/- 4 to 91 +/- 16 per cent enhancement of [3H]flunitrazepam binding. In functional studies using 36Cl-influx assay in mammalian spinal cord neurons, W. somnifera root extract increased 36Cl-influx in the absence of GABA. This effect on 36Cl-influx was blocked by bicuculline and picrotoxin; and enhanced by diazepam. These results suggest that the W. somnifera extract contains an ingredient which has a GABA-mimetic activity.en_US
dc.description.affiliationDepartment of Pharmacology, University of Texas Health Science Center.en_US
dc.identifier.citationMehta AK, Binkley P, Gandhi SS, Ticku MK. Pharmacological effects of Withania somnifera root extract on GABAA receptor complex. Indian Journal of Medical Research. 1991 Aug; 94(): 312-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/18602
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChlorides --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshReceptors, GABA-A --drug effectsen_US
dc.subject.meshgamma-Aminobutyric Acid --metabolismen_US
dc.titlePharmacological effects of Withania somnifera root extract on GABAA receptor complex.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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