Safety profile assessment of standardized root extract of Potentilla fulgens in Wistar rats: Acute and sub-acute dermal toxicity study

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dc.contributor.authorKumar, Sen_US
dc.contributor.authorNikam, YPen_US
dc.contributor.authorBaruah, Sen_US
dc.contributor.authorKushari, Sen_US
dc.contributor.authorGhose, Sen_US
dc.contributor.authorPrasad, SKen_US
dc.contributor.authorDas, Aen_US
dc.contributor.authorBanu, ZWen_US
dc.contributor.authorKalita, Jen_US
dc.contributor.authorLaloo, Den_US
dc.date.accessioned2024-11-30T11:21:19Z
dc.date.available2024-11-30T11:21:19Z
dc.date.issued2024-09
dc.description.abstractPotentilla fulgens Wall (Rosaceae), a well-known medicinal plant native to Asian regions has a rich history of traditional use for treating skin, gastrointestinal tract, and various metabolic disorders. Research has addressed that the plant is applied topically to treat conditions such as wounds, ulcers, and other skin ailments. Surprisingly, no prior investigation has explored the dermal toxicity of this plant. Therefore, the study was set to conduct the acute and subacute toxicity assessments on the ethyl acetate (EAPF) and methanol (MEPF) extracts of P. fulgenson Wistar rats. In the acute dermal toxicity study, rats received a single dose and were monitored for 14 days, while in the sub-acute study; they received a daily dose for 28 days. 2,000 and 5,000 mg/kg were tested by applying them to the shaved dorsal skin. Throughout the experiments, changes in physical appearance, behavior, and histological alterations were monitored. The results unequivocally revealed no abnormal physical or physiological changes, behavioral deviations, or mortality in any of the rats in both acute and sub-acute dermal toxicity assessments. Furthermore, there were no statistically significant differences (nsp > 0.05) in body weight, kidney, liver, spleen weights, hematological parameters, or blood biochemistry values between the treatment and control groups. These findings were further substantiated by the normal macroscopic and microscopic characteristics of the rats’ skin, kidneys, liver, and spleen. In conclusion, our study affirms that the application of EAPF and MEPF to the skin does not induce acute or subacute skin irritation nor elicit systemic toxic responses in rats.en_US
dc.identifier.affiliationsAssam Science and Technology University, Guwahati, India; Department of Pharmaceutical Chemistry, Girijananda Chowdhury Institute of Pharmaceutical Science, Girijananda Chowdhury University, Guwahati, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Indiaen_US
dc.identifier.affiliationsInstitute of Advanced Study in Science and Technology, Guwahati, Indiaen_US
dc.identifier.affiliationsAssam Science and Technology University, Guwahati, India; Department of Pharmaceutical Chemistry, Girijananda Chowdhury Institute of Pharmaceutical Science, Girijananda Chowdhury University, Guwahati, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Girijananda Chowdhury University, Guwahati, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Girijananda Chowdhury University, Guwahati, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Girijananda Chowdhury Institute of Pharmaceutical Science, Girijananda Chowdhury University, Guwahati, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Chemistry, Girijananda Chowdhury Institute of Pharmaceutical Science, Girijananda Chowdhury University, Guwahati, Indiaen_US
dc.identifier.affiliationsAssam Science and Technology University, Guwahati, India; Phytochemical Research Laboratory, Department of Pharmacognosy, Girijananda Chowdhury Institute of Pharmaceutical Science, Girijananda Chowdhury University, Guwahati, India.en_US
dc.identifier.citationKumar S, Nikam YP, Baruah S, Kushari S, Ghose S, Prasad SK, Das A, Banu ZW, Kalita J, Laloo D. Safety profile assessment of standardized root extract of Potentilla fulgens in Wistar rats: Acute and sub-acute dermal toxicity study. Journal of Applied Pharmaceutical Science. 2024 Sept; 14(9): 138-147en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237692
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber9en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.7324/JAPS.2024.184938en_US
dc.subjectPotentilla fulgensen_US
dc.subjectacute dermal toxicityen_US
dc.subjectsub-acute dermal toxicityen_US
dc.subjectbiochemical parametersen_US
dc.subjecthistologyen_US
dc.subjectHPTLC.en_US
dc.titleSafety profile assessment of standardized root extract of Potentilla fulgens in Wistar rats: Acute and sub-acute dermal toxicity studyen_US
dc.typeJournal Articleen_US
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