Evaluation of Effectiveness of Doxycycline as Empirical Therapy for Treatment in Acute Undifferentiated Febrile Illnesses in Routine Clinical Practice: A Retrospective, EMR-based, Real-world Study

Simple item page
dc.contributor.authorArulrhaj, Sundaramen_US
dc.contributor.authorImmanuel, Giftyen_US
dc.contributor.authorSaikia, Rajiven_US
dc.contributor.authorPetare, Anup Uttamen_US
dc.contributor.authorVeligandla, Krishna Chaitanyaen_US
dc.contributor.authorRathod, Rahulen_US
dc.contributor.authorBhagat, Seemaen_US
dc.contributor.authorMane, Ameyen_US
dc.date.accessioned2023-08-09T06:13:39Z
dc.date.available2023-08-09T06:13:39Z
dc.date.issued2022-08
dc.description.abstractBackground: Tetracyclines, in particular doxycycline, are recommended for the treatment of patients with acute undifferentiated febrile illness (AUFI); however, real-world studies are scarce. Methods: This retrospective, multicenter, observational study reviewed electronic medical records (April 2018 to March 2021) of adult patients (outpatient and inpatient departments [OPD and IPD]) with AUFI, treated with doxycycline monotherapy (doxycycline group) or doxycycline in combination with other antimicrobials (combination therapy group), from 7 tertiary hospitals and clinics in India. Results: Overall, 473 patients were included; 73.8% and 26.2% patients were prescribed doxycycline alone or in combination with other antimicrobials, respectively. Defervescence was achieved in 65.6% and 57.3% patients, respectively at the second (8-14 days) follow-up visit. Clinical cure rate for symptomatic resolution varied between 89.6% and 100% in OPD settings. Time taken from treatment initiation to defervescence was 3.51 ± 3.16 days for the doxycycline group and 3.46 ± 3.07 days for the combination therapy group. Both groups showed improvements in body temperature in OPD settings (84.2% and 84.5%) as well as IPD settings (97.4% and 94.1%). Adverse events in OPD patients in both groups were nausea (7.8% and 8.7%), anorexia (1.6% and 33.0%) and dyspepsia (1.6% and 67.9%). Conclusion: Doxycycline appears to be a promising candidate for treating patients with AUFI due to its demonstrated real-world effectiveness and safety profile.en_US
dc.identifier.affiliationsDept. of Cardiology, Sundaram Arulrhaj Hospital, Thoothukudi, Tamil Naduen_US
dc.identifier.affiliationsDept. of Infectious Diseases, CSI Hospital, Bangalore/Center for AIDS and Anti-Viral Research, Tuticorin, Tamil Naduen_US
dc.identifier.affiliationsSt. Augustine Hospital, Bongaigaon, Assamen_US
dc.identifier.affiliationsDr. Reddy's Laboratories Ltd., Hyderabad, Telanganaen_US
dc.identifier.citationArulrhaj Sundaram, Immanuel Gifty, Saikia Rajiv, Petare Anup Uttam, Veligandla Krishna Chaitanya, Rathod Rahul, Bhagat Seema, Mane Amey. Evaluation of Effectiveness of Doxycycline as Empirical Therapy for Treatment in Acute Undifferentiated Febrile Illnesses in Routine Clinical Practice: A Retrospective, EMR-based, Real-world Study. Indian Journal of Clinical Practice. 2022 Aug; 33(3): 14-20en_US
dc.identifier.issn0971-0876
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222074
dc.languageenen_US
dc.publisherIJCP Groupen_US
dc.relation.issuenumber3en_US
dc.relation.volume33en_US
dc.source.urihttps://ijcp.in/Pages/Post_Detail.aspx?wid=20406&Evaluation%20of%20Effectiveness%20of%20Doxycycline%20as%20Empirical%20Therapy%20for%20Treatment%20in%20Acute%20Undifferentiated%20Febrile%20Illnesses%20in%20Routine%20Clinical%20Practice:%20A%20Retrospective,%20EMR-based,%20Real-world%20Studyen_US
dc.subjectAcute undifferentiated febrile illnessen_US
dc.subjectdoxycyclineen_US
dc.subjectreal-worlden_US
dc.subjectantimicrobialsen_US
dc.titleEvaluation of Effectiveness of Doxycycline as Empirical Therapy for Treatment in Acute Undifferentiated Febrile Illnesses in Routine Clinical Practice: A Retrospective, EMR-based, Real-world Studyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJCP2022v33n3p14.pdf
Size:
860.07 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Clinical Practice