A review of gut microbiota as a therapeutic approach for Parkinson’s disease

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dc.contributor.authorGhosh, Debosreeen_US
dc.contributor.authorGhosh, Suvenduen_US
dc.contributor.authorSharma, Madhurimaen_US
dc.contributor.authorDatta, Sutapaen_US
dc.date.accessioned2025-05-12T11:41:42Z
dc.date.available2025-05-12T11:41:42Z
dc.date.issued2024-12
dc.description.abstractParkinson’s disease (PD) is a neurodegenerative disorder that affects the brain–gut axis, manifesting through both motor dysfunction and nonmotor symptoms. While several factors contribute to PD, the precise cause remains unknown. Research studies suggest that an altered gut microbiota (GM) plays a key role in PD pathophysiology. Gut dysbiosis compromises the integrity of the intestinal epithelium, increasing gastrointestinal permeability. This, in turn, activates the innate immune system, leading to systemic inflammation, whereas the adaptive immune system responds to bacterial proteins through cross-reactivity with human antigens. The altered GM promotes the accumulation of alpha-synuclein fibrils in the intestinal neural plexus, which are then transported to the central nervous system, driving the core pathological process of PD. This review focuses on the connection between gut dysbiosis, PD pathology, and current microbial-based therapeutic interventions. Furthermore, research into innovative approaches to modulate the GM and reinforce gut epithelial integrity is crucial to halting or slowing PD progression.en_US
dc.identifier.affiliationsDepartment of Physiology, Government General Degree College, Paschim Medinipur, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, Hooghly Mohsin College, Chinsura, Hooghly, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Zoology, Bethune College, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Zoology, Bethune College, Kolkata, West Bengal, Indiaen_US
dc.identifier.citationGhosh Debosree, Ghosh Suvendu, Sharma Madhurima, Datta Sutapa. A review of gut microbiota as a therapeutic approach for Parkinson’s disease. MGM Journal of Medical Sciences. 2024 Dec; 11(4): 763-771en_US
dc.identifier.issn2347-7946
dc.identifier.issn2347-7962
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247727
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber4en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.4103/mgmj.mgmj_296_24en_US
dc.subjectAlpha-synucleinen_US
dc.subjectbrain–gut–microbiota axisen_US
dc.subjectgut microbiotaen_US
dc.subjectParkinson’s diseaseen_US
dc.titleA review of gut microbiota as a therapeutic approach for Parkinson’s diseaseen_US
dc.typeJournal Articleen_US
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