Effect of cryoablation on the spatial transcriptomic landscape of the immune microenvironment in non-small cell lung cancer
No Thumbnail Available
Date
2024-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer – Medknow
Abstract
Background: Cryoablation induces antitumor immune responses. Spatial transcriptomic landscape technology has been used to determine the micron‑level panoramic transcriptomics of tissue slices in situ. Methods: The effects of cryoablation on the immune microenvironment in non‑small cell lung cancer (NSCLC) were explored by comparing the Whole Transcriptome Atlas (WTA) panel of immune cells before and after cryoablation using the spatial transcriptomic landscape. Results: The bioinformatics analysis showed that cryoablation significantly affected the WTA of immune cells, particularly genes related to cellular components, biological processes, molecular functions, proliferation and migration, and cytokine‑cytokine receptor interaction signaling pathways. Conclusions: The findings of this study suggest that cryoablation significantly impacts the biological functions of immune cells in the tumor microenvironment of NSCLC through multiple mechanisms.
Description
Keywords
Cryoablation, immune microenvironment, non‑small cell lung cancer, spatial transcriptomic landscape
Citation
Zhou Jun, Wang Shengxi, Liu Ming, Li Zhaopei. Effect of cryoablation on the spatial transcriptomic landscape of the immune microenvironment in non-small cell lung cancer. Journal of Cancer Research and Therapeutics. 2024 Dec; 20(7): 2141-2147