Molecular & evolutionary genetics & drug resistance of the gastric pathogen, Helicobacter pylori.

Simple item page
dc.contributor.authorDatta, Sen_US
dc.contributor.authorChowdhury, Aen_US
dc.contributor.authorMukhopadhyay, A Ken_US
dc.contributor.authorBhattacharya, S Ken_US
dc.contributor.authorBerg, D Een_US
dc.contributor.authorNair, G Ben_US
dc.date.accessioned2002-03-31en_US
dc.date.accessioned2009-05-27T08:55:07Z
dc.date.available2002-03-31en_US
dc.date.available2009-05-27T08:55:07Z
dc.date.issued2002-03-31en_US
dc.description248 references.en_US
dc.description.abstractHelicobacter pylori colonizes the gastric mucosa of more than half of all people worldwide and is the major cause of peptic ulcer disease and an early risk factor for gastric cancer, even though most infections are asymptomatic. Infection occurs preferentially in early childhood and once established tends to persist for years or decades. Much of the pathology H. pylori causes probably results from the host response to infection, which is affected by bacterial genotype, human host characteristics and environmental conditions. H. pylori is one of the most genetically diverse of bacterial species, with different genotypes predominating in different parts of the world. In particular, strains from India differ from those of Europe and East Asia in DNA sequence of several diagnostic gene segments. This outcome invites speculation about H. pylori origins and the possibility of Indian-specific genes that might be uncommon in Western strains. Much has been learned from H. pylori genome sequences, along with epidemiological, mutational, molecular and immunologic analyses. Candidate bacterial colonization and virulence genes and host responses are being identified, and the hypotheses being developed are amenable to tests in cell culture and animal models. These research efforts, many of which are collaborative and international, provide insights into mechanisms of establishment and persistence of H. pylori infection and virulence, and should lead to new, far more potent and cost effective anti-Helicobacter therapies or vaccines, and thereby major improvement in human health worldwide.en_US
dc.description.affiliationNational Institute of Cholera & Enteric Diseases (ICMR), Institute of Post Graduate Medical Education & Research, Kolkata, India.en_US
dc.identifier.citationDatta S, Chowdhury A, Mukhopadhyay AK, Bhattacharya SK, Berg DE, Nair GB. Molecular & evolutionary genetics & drug resistance of the gastric pathogen, Helicobacter pylori. Indian Journal of Medical Research. 2002 Mar; 115(): 73-101en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/26071
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshDrug Resistance, Microbial --geneticsen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshHelicobacter pylori --drug effectsen_US
dc.titleMolecular & evolutionary genetics & drug resistance of the gastric pathogen, Helicobacter pylori.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, P.H.S.en_US
dc.typeReviewen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Medical Research