Childhood lupus: Experience from eastern India.

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dc.contributor.authorMondal, Rakesh
dc.contributor.authorNandi, Madhumita
dc.contributor.authorGanguli, Suhas
dc.contributor.authorGhosh, Alokendu
dc.contributor.authorHazra, Avijit
dc.date.accessioned2012-10-31T07:46:47Z
dc.date.available2012-10-31T07:46:47Z
dc.date.issued2010-08
dc.description.abstractObjective. To delineate the clinical behavior of SLE in children from Eastern India and to the differences in disease pattern. Methods. In the present study, all 44 patients of pediatric SLE who were diagnosed over a period of 5 years in our pediatric rheumatology clinic were followed prospectively. The resultant database was analyzed using standard statistical methods. Results. About 3.9% of all rheumatology cases dealt with in the clinic in the last five yrs (n=1063) were SLE. The number of children in 5-8 yrs and 8-12 yrs age groups were 13 and 27, respectively. The overall female (n=35) to male (n=9) ratio in this study was 3.8:1. Renal, hematological and Neuropsychiatric features were most common major organ manifestations(54%,54% and 25% respectively). Joints and skin were the most common minor organs involved. Two case were ANA negative SLE. Among the typical features of ANA negative disease, only nephritis was found in these patients. Anti dsDNA was positive in 50 % cases (n=21). C3 levels were studied in all cases with nephritis (n=22) and 68 % (n=15) had hypocomplementemia. Anti Ro and anti La antibodies were positive in two cases of neonatal lupus. APLA, Anti Sm antibody and anti U1RNP were negative in the cases where testing was done. Conclusions. This study has tried to delineate the disease trends of childhood lupus from Eastern India. Certain important trends have emerged which are different from other contemporary Indian and International observations.en_US
dc.identifier.citationMondal Rakesh, Nandi Madhumita, Ganguli Suhas, Ghosh Alokendu, Hazra Avijit. Childhood lupus: Experience from eastern India. Indian Journal of Pediatrics. 2010 Aug; 77(8): 889-891.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142656
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/icb/t10/i8/icbt10i8p889.pdfen_US
dc.subjectChildhood lupusen_US
dc.subjectSLEen_US
dc.subject.meshAntibodies, Antinuclear --blood
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshLupus Erythematosus, Systemic --complications
dc.subject.meshLupus Erythematosus, Systemic --congenital
dc.subject.meshLupus Erythematosus, Systemic --immunology
dc.subject.meshLupus Nephritis --complications
dc.subject.meshLupus Nephritis --immunology
dc.subject.meshLupus Vasculitis, Central Nervous System --complications
dc.subject.meshLupus Vasculitis, Central Nervous System --immunology
dc.subject.meshMale
dc.subject.meshProspective Studies
dc.subject.meshSex Distribution
dc.titleChildhood lupus: Experience from eastern India.en_US
dc.typeArticleen_US
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