Effects of release modifier on Carvedilol release from Kollidon SR based matrix.

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dc.contributor.authorDas, Urmi
dc.contributor.authorHossain, Mohammad Salim
dc.date.accessioned2014-07-19T10:23:05Z
dc.date.available2014-07-19T10:23:05Z
dc.date.issued2012-07
dc.description.abstractSustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.en_US
dc.identifier.citationDas Urmi, Hossain Mohammad Salim. Effects of release modifier on Carvedilol release from Kollidon SR based matrix. International Current Pharmaceutical Journal. 2012 July 1(8): 186-192.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/152857
dc.language.isoenen_US
dc.source.urihttps://www.icpjonline.com/documents/Vol1Issue8/01Abstract.htmen_US
dc.subjectMicrocrystalline celluloseen_US
dc.subjectCarvedilolen_US
dc.subjectsustain releaseen_US
dc.subjectHPMCen_US
dc.subjectswelling studyen_US
dc.subjectFickian releaseen_US
dc.titleEffects of release modifier on Carvedilol release from Kollidon SR based matrix.en_US
dc.typeArticleen_US
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