Neuromyelitis optica in a paediatric patient: a case report

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dc.contributor.authorRanabijuli, PKen_US
dc.contributor.authorSitaram, APen_US
dc.contributor.authorNazparveen, LAen_US
dc.contributor.authorKumari, S.en_US
dc.date.accessioned2025-05-09T11:05:43Z
dc.date.available2025-05-09T11:05:43Z
dc.date.issued2024-10
dc.description.abstractNeuromyelitis optica is a multifocal demyelinating disease of the central nervous system that predominantly affects the spinal cord and optic nerves, with variable clinical features including motor weakness in limbs, bowel and bladder affection and loss of vision. The disease is characterized by poor or no recovery. Magnetic resonance imaging (MRI) of spine with contrast shows hyperintense lesions involving contiguous segments with a normal MRI brain. CSF studies shows anti aquaporin 4 antibodies. Visual evoked potential of eyes shows marked reduction of optic nerve function. We report a case of eight year old girl who presented with diminished vision in eyes (right >left) and weakness in all four limbs. Clinical features and investigations were suggestive of NMO. She was treated with inj. methylprednisolone for 5 days followed by oral prednisolone in tapering dose for 6 weeks. The child improved of hemiparetic gait and power in the left side. Vision in the left eye did not deteriorate further. Repeat MRI showed the resolution of previous spinal lesions. Follow up of the child over seven years has multiple admissions due to relapses. In the third admission child was given again 5 days of inj. methylprednisolone followed by azathioprine for two months. On the seventh admission due to relapse, inj. rituximab 500 mg and inj. methylprednisolone 500 mg was given and repeated every 6 months. In the last follow up in June 2024, the child is clinically stable with improvement in gait and no further deterioration of vision and no bowel or bladder affection.en_US
dc.identifier.affiliationsDepartment of Paediatrics, JagjivanRam Railway Hospital, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrics, JagjivanRam Railway Hospital, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrics, JagjivanRam Railway Hospital, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrics, JagjivanRam Railway Hospital, Mumbai, Maharashtra, Indiaen_US
dc.identifier.citationRanabijuli PK, Sitaram AP, Nazparveen LA, Kumari S.. Neuromyelitis optica in a paediatric patient: a case report . International Journal of Contemporary Pediatrics. 2024 Oct; 11(10): 1467-1470en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246324
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.18203/2349-3291.ijcp20242745en_US
dc.subjectNeuromyelitis opticaen_US
dc.subjectFollow upen_US
dc.subjectRelapseen_US
dc.subjectMethylprednisoloneen_US
dc.subjectPrednisoloneen_US
dc.subjectAzathioprineen_US
dc.subjectRituximaben_US
dc.titleNeuromyelitis optica in a paediatric patient: a case reporten_US
dc.typeJournal Articleen_US
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