Comparison of the Minimum Fungicidal Concentration of Clotrimazole, Ketoconazole, Miconazole and Terbinafine Against Clinical Isolates of Dermatophytes.

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dc.contributor.authorPatankar, M
dc.contributor.authorAhluwalia, A
dc.contributor.authorBhargava, A
dc.date.accessioned2015-04-18T06:20:51Z
dc.date.available2015-04-18T06:20:51Z
dc.date.issued2014-02
dc.description.abstractSuperficial fungal infections affect millions of people worldwide. Earlier most dermatophyte strains had relatively restricted geographical distribution. But currently, dermatophytosis has become one of the most common human infectious diseases worldwide. Fungal infections are common in hot and humid climate of tropical countries like India. Topical and systemic therapies are commonly used to treat dermatophyte infections.Clotrimazole is one of the most commonly used topical antifungal drugs. This study compared the minimum fungicidal concentration (MFC) of Clotrimazole with Miconazole, Ketoconazole and Terbinafine in skin dermatophytes. The study demonstrated that Clotrimazole had lower MFCs as compared to Ketoconazole and Miconazole against Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum canis. Clotrimazole had comparable MFCs versus Terbinafine against Trichophyton rubrum but it had lower MFCs against Trichophyton mentagrophytes and Microsporum canis. Thus, Clotrimazole is an effective antifungal agent for dermatophytosis even today.The efficacy of Clotrimazole even against strains with intermediate resistance or resistance to the older azole anti fungal drugs reiterate the current decisions of empirical treatment with topical Clotrimazole for the management of superficial dermatophyte infections.en_US
dc.identifier.citationPatankar M, Ahluwalia A, Bhargava A. Comparison of the Minimum Fungicidal Concentration of Clotrimazole, Ketoconazole, Miconazole and Terbinafine Against Clinical Isolates of Dermatophytes. Indian Medical Gazette. 2014 Feb ; 148 (2): 65-68.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/157587
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ice/t14/i2/icet14i2p65.pdfen_US
dc.subjectdermatophytosisen_US
dc.subjectclotrimazoleen_US
dc.subjectminimum fungicidal concentration (MFC)en_US
dc.subject.meshAntifungal Agents --pharmacology
dc.subject.meshArthrodermataceae --drug effects
dc.subject.meshArthrodermataceae --isolation & purification
dc.subject.meshClotrimazole --pharmacology
dc.subject.meshDermatomycoses --drug effects
dc.subject.meshDermatomycoses --isolation & purification
dc.subject.meshKetoconazole --pharmacology
dc.subject.meshMiconazole --pharmacology
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMicrosporum --drug effects
dc.subject.meshMicrosporum --isolation & purification
dc.subject.meshNaphthalenes --analogs & derivatives
dc.subject.meshNaphthalenes --pharmacokinetics
dc.titleComparison of the Minimum Fungicidal Concentration of Clotrimazole, Ketoconazole, Miconazole and Terbinafine Against Clinical Isolates of Dermatophytes.en_US
dc.typeArticleen_US
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