Inflammasome, Inflammation, Infection and Mefenamic Acid

Simple item page
dc.contributor.authorKasture, Prabhuen_US
dc.contributor.authorMehta, Ketanen_US
dc.contributor.authorGowda, Ambannaen_US
dc.date.accessioned2023-06-17T07:19:33Z
dc.date.available2023-06-17T07:19:33Z
dc.date.issued2022-03
dc.description.abstractNucleotide-binding oligomerization domain like receptors (NLRs) –intracellular proteins, are a recently discovered class of innate immune receptors that play a crucial role in initiating the inflammatory response following pathogen recognition. The dysregulation of NLRP3 inflammasome can cause uncontrolled inflammation and drive the development of a wide variety of human diseases. Mefenamic acid which belongs to fenamate group inhibits the NLRP3 inflammasome by inhibiting efflux of chloride ions and influx of calcium ions through blocking VRAC and TRPM2 respectively. Thus, Mefenamic acid provides a potentially practical pharmacological approach for treating NLRP3- driven diseasesen_US
dc.identifier.affiliationsHead Medical Affairs and Pharmacovigilance, Blue Cross Laboratories Pvt Ltd, Mumbai, Maharashtraen_US
dc.identifier.affiliationsConsulting Physician, Asian Heart Institute, Suchak Hospital and Health Harmony Clinic, Mumbai, Maharashtraen_US
dc.identifier.affiliationsConsulting Physician & Diabetologist, Sparsh Hospital Infantry Road, Bengaluru, Karnatakaen_US
dc.identifier.citationKasture Prabhu, Mehta Ketan, Gowda Ambanna. Inflammasome, Inflammation, Infection and Mefenamic Acid. Journal of the Association of Physicians of India. 2022 Mar; 70(3): 78-81en_US
dc.identifier.issn0004 – 5772
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216141
dc.languageenen_US
dc.publisherAssociation of Physicians of Indiaen_US
dc.relation.issuenumber3en_US
dc.relation.volume70en_US
dc.source.urihttps://www.japi.org/x2b49484/inflammasome-inflammation-infection-and-mefenamic-aciden_US
dc.titleInflammasome, Inflammation, Infection and Mefenamic Aciden_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
JAPI2022v70n3p78.pdf
Size:
566.07 KB
Format:
Adobe Portable Document Format
Download
Collections
Journal of the Association of Physicians of India