Utility of QuantiFERON TB gold test in a south Indian patient population of ocular inflammation.

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dc.contributor.authorBabu, Kalpana
dc.contributor.authorSatish, Vidya
dc.contributor.authorSatish, S
dc.contributor.authorSubbaKrishna, D K
dc.contributor.authorAbraham, Mariamma Philips
dc.contributor.authorMurthy, Krishna R
dc.date.accessioned2011-12-20T06:38:19Z
dc.date.available2011-12-20T06:38:19Z
dc.date.issued2009-11
dc.description.abstractAim: To study the utility of interferon-γ release assays (QuantiFERON TB gold test) in a south Indian patient population of intraocular inflammation. Design: Evaluation of a diagnostic test- a pilot study from January 2007 to October 2008. Materials and Methods: QuantiFERON TB gold test was performed on the following groups of patients following an informed consent. Group A included healthy volunteers without any exposure to tuberculosis (TB) or past history of TB (n=22). Group B included patients with active systemic TB diagnosed by the demonstration of acid-fast bacilli or by the histopathology finding of caseation with granuloma formation from the sputum, lymph node, skin or intestinal biopsies (n=26). Group C included patients with uveitis of known etiologies other than intraocular TB without any history of exposure to active TB (n=21). Group D included patients with a diagnosis of presumed intraocular TB, who responded to antitubercular therapy by decreased or no recurrences following treatment and with a minimum of nine months follow-up following initiation of antitubercular therapy (n=39). Results: The sensitivity and specificity of the QuantiFERON TB gold test to pick up active systemic TB was 58% and 77% respectively. The sensitivity and specificity of the QuantiFERON TB gold test to pickup intraocular TB was 82% and 76% respectively. Conclusions: QuantiFERON TB gold test alone may not be specific for intraocular TB. The significance of this test in a case scenario needs to be interpreted with clinical presentation and other evidences for intraocular TB.en_US
dc.identifier.citationBabu Kalpana, Satish Vidya, Satish S, SubbaKrishna D K, Abraham Mariamma Philips, Murthy Krishna R. Utility of QuantiFERON TB gold test in a south Indian patient population of ocular inflammation. Indian Journal of Ophthalmology. 2009 Nov; 57(6): 427-430.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135993
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812760/en_US
dc.subjectInterferon-γ release assaysen_US
dc.subjectintraocular tuberculosisen_US
dc.subjectQuantiFERON TB gold testen_US
dc.subject.meshDiagnosis, Differential
dc.subject.meshDiagnostic Techniques, Ophthalmological --instrumentation
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshIndia --epidemiology
dc.subject.meshInterferon-gamma --blood
dc.subject.meshPilot Projects
dc.subject.meshPredictive Value of Tests
dc.subject.meshReagent Kits, Diagnostic
dc.subject.meshRetrospective Studies
dc.subject.meshSensitivity and Specificity
dc.subject.meshTuberculosis, Ocular --blood
dc.subject.meshTuberculosis, Ocular --diagnosis
dc.subject.meshTuberculosis, Ocular --epidemiology
dc.titleUtility of QuantiFERON TB gold test in a south Indian patient population of ocular inflammation.en_US
dc.typeArticleen_US
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