Atopic diseases and the risk of alopecia areata among pre-teens and teenagers in Taiwan

Simple item page
dc.contributor.authorLu, YYen_US
dc.contributor.authorWu, MKen_US
dc.contributor.authorLu, CCen_US
dc.contributor.authorWang, WTen_US
dc.contributor.authorWu, CH.en_US
dc.date.accessioned2025-08-13T11:21:47Z
dc.date.available2025-08-13T11:21:47Z
dc.date.issued2025-06
dc.description.abstractBackground: Alopecia areata (AA), a disorder of non-scarring hair loss with a variable relapsing and remitting course, is a common autoimmune disease in children. Although it often presents as several focal small patchy bald lesions, early onset AA can lead to a total loss of scalp hair, even body hairs, a severe subtype. Atopic diseases are common concurrent disorders in AA, especially among those with early onset severe type of hair loss. Whether atopic diseases increase the risk of AA in the paediatric population of Taiwan, remains unclear. Objective: To identify if atopic diseases increase the risk of AA among pre-teens and teenagers in Taiwan. Methods: From Taiwan National Health Insurance Database 2010, we used the claims data to clarify the risk of AA in pre- teens and teenagers with atopic diseases (atopic dermatitis, allergic conjunctivitis, asthma, allergic rhinitis and food allergy) as compared to the general population. Cox proportional hazards model yielded hazard ratios (HRs) to address the impact of atopic diseases, sex and age on AA risk after adjusting for covariates and subsequent stratified analyses. Results: Overall, 21,070 children (10,535 patients with atopic diseases and 10,535 normal cohort) aged over nine years were recruited. During a follow-up of 15 years, 39 (0.37%) cases were identified to have AA in the atopic diseases group, while 11 (0.10%) had developed AA in the normal cohort. As compared with the normal population, the paediatric population with atopic diseases had a 9.66-fold higher risk of developing AA. The risk was greater for boys and increased with advanced age. In the atopic diseases group, pre-teens and teenagers with food allergies and Sjogren’s syndrome were more likely to have AA. Limitations: Only one ethnic group. Conclusion: All atopic diseases enhanced the risk of developing AA in Taiwan pre-teens and teenagers. Children with atopic diseases should be monitored to look for the development of AA.en_US
dc.identifier.affiliationsDepartment of Dermatology, Kaohsiung Veterans General Hospital; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwanen_US
dc.identifier.affiliationsDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Niaosong Dist, Kaohsiung, Taiwanen_US
dc.identifier.affiliationsDepartment of Orthopaedics and Traumatology, National Yang Ming Chiao Tung University Hospital, Yilan City; Department of Orthopaedics, School of Medicine, National Yang Ming Chiao Tung University, Neihu Dist, Taipei, Taiwanen_US
dc.identifier.affiliationsDepartment of Radiology, Tri-Service General Hospital, Neihu Dist, Taipei, Taiwanen_US
dc.identifier.affiliationsDepartment of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University; Division of Neurosurgery, Sanmin Dist, Kaohsiung, Taiwan; Department of Surgery, Kaohsiung Medical University Hospital, Sanmin Dist, Kaohsiung, Taiwan.en_US
dc.identifier.citationLu YY, Wu MK, Lu CC, Wang WT, Wu CH.. Atopic diseases and the risk of alopecia areata among pre-teens and teenagers in Taiwan. Indian Journal of Dermatology, Venereology and Leprology. 2025 Jun; 91(3): 294-299en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253755
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists (IADVL), India.en_US
dc.relation.issuenumber3en_US
dc.relation.volume91en_US
dc.source.urihttps://dx.doi.org/10.25259/IJDVL_1215_2023en_US
dc.subjectAlopecia areataen_US
dc.subjectatopic diseasesen_US
dc.subjectcohorten_US
dc.subjectrisken_US
dc.titleAtopic diseases and the risk of alopecia areata among pre-teens and teenagers in Taiwanen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijdvl2025v91n3p294.pdf
Size:
371.56 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Dermatology, Venereology and Leprology