Aciclovir resistance among Indian strains of Herpes simplex virus as determined using a dye uptake assay.

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dc.contributor.authorAbraham, A Men_US
dc.contributor.authorKavitha, Sen_US
dc.contributor.authorJoseph, Pen_US
dc.contributor.authorGeorge, Ren_US
dc.contributor.authorPillay, Den_US
dc.contributor.authorMalathi, Jen_US
dc.contributor.authorJesudason, M Ven_US
dc.contributor.authorSridharan, Gen_US
dc.date.accessioned2007-07-29en_US
dc.date.accessioned2009-05-28T09:07:58Z
dc.date.available2007-07-29en_US
dc.date.available2009-05-28T09:07:58Z
dc.date.issued2007-07-29en_US
dc.description.abstractResistance to aciclovir (ACV) among Herpes simplex virus (HSV) isolates is increasingly being reported in the literature particularly in immunocompromised patients. However, there is only limited data available from India despite widespread use of ACV in our hospital. A cross-sectional study was hence conducted to determine the aciclovir (ACV) susceptibility of HSV 1 and 2 isolates using a dye uptake (DU) assay. This study showed a 3.0% prevalence of ACV resistance among HSV-1 strains (2/66, median IC 50 0.098 microg/mL) while in HSV-2 strains, it was 7.8% (5/64, median IC 50 0.195 microg/mL). The IC 50 for the HSV-1 and HSV-2 strains resistant to ACV was greater than or equal to 6.25 microg/mL.en_US
dc.description.affiliationDepartment of Clinical Virology, Christian Medical College, Vellore - 632 004, Tamil Nadu, India. asha_ma@yahoo.comen_US
dc.identifier.citationAbraham AM, Kavitha S, Joseph P, George R, Pillay D, Malathi J, Jesudason MV, Sridharan G. Aciclovir resistance among Indian strains of Herpes simplex virus as determined using a dye uptake assay. Indian Journal of Medical Microbiology. 2007 Jul; 25(3): 260-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/53477
dc.language.isoengen_US
dc.source.urihttps://www.ijmm.orgen_US
dc.subject.meshAcyclovir --pharmacologyen_US
dc.subject.meshAntiviral Agents --pharmacologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDrug Resistance, Viralen_US
dc.subject.meshHerpes Simplex --virologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMicrobial Sensitivity Tests --methodsen_US
dc.subject.meshSimplexvirus --drug effectsen_US
dc.subject.meshVirology --methodsen_US
dc.titleAciclovir resistance among Indian strains of Herpes simplex virus as determined using a dye uptake assay.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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