Anti-keratin antibodies in patients with rheumatoid arthritis.

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dc.contributor.authorSharma, B Len_US
dc.contributor.authorRani, Ren_US
dc.contributor.authorMisra, Ren_US
dc.contributor.authorAggarwal, Aen_US
dc.date.accessioned2000-06-02en_US
dc.date.accessioned2009-05-27T08:14:25Z
dc.date.available2000-06-02en_US
dc.date.available2009-05-27T08:14:25Z
dc.date.issued2000-06-02en_US
dc.description.abstractAs the proportion of patients with rheumatoid arthritis (RA) who have anti-keratin antibodies (AKA) varies in different ethnic groups, we studied its occurrence in a hospital populations with RA and its association with different disease variables. Sera from 84 consecutive patients with RA, 100 healthy controls and 85 disease controls (polyarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis) were tested for AKA by an indirect immunofluorescence assay that used rat esophagus as substrate. The proportion of patients with RA who had AKA (47/84) was higher than in healthy controls (2/100; P < 0.001) and in disease controls (2/85; P < 0.001). The frequency of AKA positivity was higher among patients who had severe disease (P < 0.05) and rheumatoid factor. Anti-keratin antibody is present in 56 per cent of our patients with RA and is associated with severe disease.en_US
dc.description.affiliationDepartment of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.en_US
dc.identifier.citationSharma BL, Rani R, Misra R, Aggarwal A. Anti-keratin antibodies in patients with rheumatoid arthritis. Indian Journal of Medical Research. 2000 Jun; 111(): 215-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23742
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshArthritis, Rheumatoid --immunologyen_US
dc.subject.meshAutoantibodies --analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKeratins --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleAnti-keratin antibodies in patients with rheumatoid arthritis.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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