Comparative evaluation of cell proliferative indices and epidermal growth factor receptor expression in gastric carcinoma.

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dc.contributor.authorPrakash, Ien_US
dc.contributor.authorMathur, R Pen_US
dc.contributor.authorKar, Pen_US
dc.contributor.authorRanga, Sen_US
dc.contributor.authorTalib, V Hen_US
dc.date.accessioned1997-10-28en_US
dc.date.accessioned2009-05-29T12:32:24Z
dc.date.available1997-10-28en_US
dc.date.available2009-05-29T12:32:24Z
dc.date.issued1997-10-28en_US
dc.description.abstractA total of 62 patients of gastric carcinoma were studied to find a correlation between newer prognostic indicators like cell proliferative indices including Nucleolar Organizer regions (AgNORs), Ki 67 Labelling Index and Epidermal Growth Factor Receptor (EGFR) expression with the various, histopathological criteria and compared with 30 controls of non neoplastic gastric diseases. EGFR expression was positive in 48(77.4%) cases. The Ki 67 labelling indices ranged from 0 to 50% with a mean of 21.35 +/- 17.88% among the cases. AgNOR counts ranged from 1.64 to 4.49 with a mean of 3.41 +/- 0.81 among the cases. Positive EGFR expression correlated strongly with differentiation of the tumour, poorly differentiated tumours showing a higher positivity. EGFR positivity also showed good correlation with metastasis as well as with the invasiveness of the tumour. Ki 67 labelling indices correlated significantly with metastatic status, microscopic types and degree of differentiation of the tumour. A strong correlation was observed between AgNOR counts and metastasis as well as the microscopic type of the tumour. EGFR expression correlated strongly with Ki 67 scores and weakly with AgNOR counts among the patients of gastric carcinoma.en_US
dc.description.affiliationDepartment of Laboratory Medicine, Safdarjang Hospital, New Delhi.en_US
dc.identifier.citationPrakash I, Mathur RP, Kar P, Ranga S, Talib VH. Comparative evaluation of cell proliferative indices and epidermal growth factor receptor expression in gastric carcinoma. Indian Journal of Pathology & Microbiology. 1997 Oct; 40(4): 481-90en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74698
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshHumansen_US
dc.subject.meshKi-67 Antigen --analysisen_US
dc.subject.meshMitotic Indexen_US
dc.subject.meshNeoplasm Invasivenessen_US
dc.subject.meshNeoplasm Metastasisen_US
dc.subject.meshNucleolus Organizer Region --pathologyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshReceptor, Epidermal Growth Factor --analysisen_US
dc.subject.meshStomach Diseases --pathologyen_US
dc.subject.meshStomach Neoplasms --pathologyen_US
dc.subject.meshTumor Markers, Biological --analysisen_US
dc.titleComparative evaluation of cell proliferative indices and epidermal growth factor receptor expression in gastric carcinoma.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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