Butea monosperma Reduces Haloperidol and Sulpiride Induced Hyperprolactinemia.

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dc.contributor.authorTiwari, Prashanten_US
dc.contributor.authorDubey, Sunil Kumaren_US
dc.contributor.authorSahu, Pratap Kumaren_US
dc.date.accessioned2020-11-18T10:25:15Z
dc.date.available2020-11-18T10:25:15Z
dc.date.issued2019-04
dc.description.abstractBackground: Prolonged administration of neurolepticdrugs cause disrupted D dopamine receptor which 2leads to increased prolactin level, causesgyanaecomastia. Presently, dopamine receptor agonistis the choice of treatment for hyperprolactinemia. Aimand Objectives: The study aims to determine the antihyperprolactinemic effect of methanolic extract ofButea monosperma (MEBM) against haloperidol(HPL) and sulpiride (SPD) induced hyperprolactinemiaand to correlate with its active constituents. Materialand Methods: To induce hyperprolactinemia HPL 5mg/kg for 16 continuous days and SPD 20 mg/kg for 28continuous days was administred. MEBM 200mg/kg/day and 400 mg/kg/day were administered for16 and 28 days respectively half an hour beforeadministration of HPL and SPD. The serum prolactin(PRL) level, dopamine (DA) level and antioxidantstatus in the rat brain, hematological parameters weremeasured and histological examination of the anteriorpituitary gland, adrenal gland and spleen were done. Inaddition, antioxidant enzymes like superoxidedismutase (SOD) and catalase (CAT) were alsoestimated. Results: MEBM decreases serum PRL leveland increased DA level in brain significantly. Further,MEBM also restored SOD and CATstatus significantly.The inflammatory markers induced by HPL and SPDwere suppressed by MEBM. Discussion: Neuronal DAinhibition by neuroleptic drugs decreases the release ofDAwhich leads to hyperprolactinemia. MEBM (butrin)may activate DA neurones to ameliorate hyperprolactinaemia. The dopaminergic, anti-oxidant andanti-inflammatory effect of MEBM may be attributed toits anti-hyperprolactinemic effect. Conclusion: Buteamonosperma possesses anti-hyperprolactinemic effectwhich may be attributed to its marker constituent likeButrin.en_US
dc.identifier.affiliationsDepartment of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar- 751030 (Orissa) Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacy, Birla Institute of Technology and Science, Pilani-333031(Rajasthan) Indiaen_US
dc.identifier.citationTiwari Prashant, Dubey Sunil Kumar, Sahu Pratap Kumar. Butea monosperma Reduces Haloperidol and Sulpiride Induced Hyperprolactinemia.. Journal of Krishna Institute of Medical Sciences University. 2019 Apr; 8(2): 40-52en_US
dc.identifier.issn2231-4261
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215602
dc.languageenen_US
dc.publisherKrishna Institute of Medical Sciences Universityen_US
dc.relation.issuenumber2en_US
dc.relation.volume8en_US
dc.source.urihttps://www.jkimsu.com/jkimsu-vol8no2/JKIMSU,%20Vol.%208,%20No.%202,%20April-June%202019%20Page%2040-52.pdfen_US
dc.subjectHaloperidolen_US
dc.subjectsulpirideen_US
dc.subjectprolactinen_US
dc.subjectdopamineen_US
dc.subjectcatalaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.titleButea monosperma Reduces Haloperidol and Sulpiride Induced Hyperprolactinemia.en_US
dc.typeJournal Articleen_US
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