Oxidative stress and antioxidant status in cardiovascular diseases in population of western Nepal.

Simple item page
dc.contributor.authorRisal, Sen_US
dc.contributor.authorAdhikari, Den_US
dc.contributor.authorAlurkar, V Men_US
dc.contributor.authorSingh, P Pen_US
dc.date.accessioned2009-05-28T04:09:50Z
dc.date.available2009-05-28T04:09:50Z
dc.date.issued2006-07-08en_US
dc.descriptionKathmandu University Medical Journal.en_US
dc.description.abstractOBJECTIVES: To observe if there is any connectivity between oxidative stress and cardiovascular diseases (CVDs). MATERIALS AND METHODS: Patients suffering from different cardiovascular diseases (hypertension, ischemic heart disease, rheumatic heart disease) attending Manipal Teaching Hospital, Pokhara and strictly matched controls were selected for this study. Oxidative stress (OS) was measured by plasma thiobarbituric acid reacting substances (TBARS) where as antioxidant status was measured by estimating vitamin E, vitamin C and total antioxidant activity (TAA) in plasma. RESULTS: The mean level of TBARS, TAA, vitamin C and E were 2.20+0.43 nmol/ml, 547+98 mol/l, 0.88+0.15 mg/dl and 0.75+0.20 mg/dl respectively in patients. The respective values in controls were 1.86+0.43 nmol/ml, 859+139 mol/l, 0.94+0.15 mg/dl and 1.10+0.30 mg/dl. Although the OS seems to be raised in patients, is practically insufficient to oxidize biomolecules and induce CVDs. Despite vitamin C and E levels being well within normal limits, the TAA was significantly and considerably lower in patients. This is a highly interesting observation suggesting that dietary antioxidants other than these vitamins were preferentially consumed to control OS because procedure for TAA used in this study practically measures only total dietary antioxidants. CONCLUSION: OS does not appear to be an etiological factor for the cardiovascular diseases; rather slightly raised OS in patients seems to be a consequence. Further the raised OS was not due to lower nutrient antioxidant (vit. C and vit. E) in the local population studied herein.en_US
dc.description.affiliationDepartment of Biochemistry, Nepal Medical College, Attarkhel, Jorpati, Kathmandu, Nepal. srisall@hotmail.comen_US
dc.identifier.citationRisal S, Adhikari D, Alurkar VM, Singh PP. Oxidative stress and antioxidant status in cardiovascular diseases in population of western Nepal. Kathmandu University Medical Journal. 2006 Jul-Sep; 4(3): 271-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/46523
dc.language.isoengen_US
dc.source.urihttps://www.kumj.com.npen_US
dc.source.urihttps://kumj.com.np/ftp/issue/15/271-274.pdfen_US
dc.subject.meshAdulten_US
dc.subject.meshAntioxidants --metabolismen_US
dc.subject.meshAscorbic Acid --blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCausalityen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshFemaleen_US
dc.subject.meshFree Radicals --adverse effectsen_US
dc.subject.meshHospitals, Teachingen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Ischemia --epidemiologyen_US
dc.subject.meshNepal --epidemiologyen_US
dc.subject.meshOxidative Stress --physiologyen_US
dc.subject.meshRheumatic Heart Disease --epidemiologyen_US
dc.subject.meshSmoking --adverse effectsen_US
dc.subject.meshThiobarbituric Acid Reactive Substances --metabolismen_US
dc.subject.meshVitamin A Deficiency --blooden_US
dc.subject.meshVitamin E --blooden_US
dc.subject.meshVitamin E Deficiency --blooden_US
dc.titleOxidative stress and antioxidant status in cardiovascular diseases in population of western Nepal.en_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
kumj2006v4n3p.271.pdf
Size:
124.79 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Kathmandu University Medical Journal