Exfoliation Technique of Composing and Depictions of Clopidogrel Bisulphate Afloat Microspheres

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dc.contributor.authorHarsha, wamygari Satyaen_US
dc.contributor.authorAhad, Hindustan Abdulen_US
dc.contributor.authorHaranath, Chinthaginjalaen_US
dc.contributor.authorDasari, Rahul Raghaven_US
dc.contributor.authorGowthami, Madanaen_US
dc.contributor.authorVaram, Naga Jyothien_US
dc.contributor.authorBitranganti, Samhitha Raoen_US
dc.contributor.authorMusa, Gamaa Birir Mohameden_US
dc.date.accessioned2020-11-18T10:18:13Z
dc.date.available2020-11-18T10:18:13Z
dc.date.issued2020-04
dc.description.abstractGastro retention dosage forms are obligatory for holding the drug in the stomach for area definite drug discharge by afloat technique. Floating microspheres (FM) of Clopidogrel Bisulphate (CB) were fabricated to increase the drug’s reach to blood and to show elongated drug release.METHODSFM of CB were prepared by the ion gelation (exfoliation) method using ethyl cellulose, carrageenan gum, and sodium alginate. The drug-loaded FM were designed and assessed for their physicochemical characteristics including drug-excipient friendly behaviour by Differential Scanning Calorimetry (DSC) and Fourier Transform Infra-Red (FTIR).RESULTSThe DSC and FTIR study revealed the compatibility of CB with the excipients used. The percentage yield of FM from all formulations was good and showed satisfactory buoyancy and floating time. % CB release for the formulations was found up to 98.5% (F8) till 10th hour. The release kinetics revealed that CB discharge from the devices was best fitted to Hixson Crowell’s model with regression values ranging from 0.887 to 0.989.CONCLUSIONSFM with CB can be formulated using sodium alginate, ethyl cellulose and carrageenan gum by exfoliation gelation method.en_US
dc.identifier.affiliationsDepartment of Pharmaceutics, RIPER- Autonomous, Ananthapuramu, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Industrial Pharmacy, RIPER- Autonomous, Ananthapuramu, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Industrial Pharmacy, RIPER- Autonomous, Ananthapuramu, Andhra Pradesh, India.en_US
dc.identifier.affiliationsDepartment of Industrial Pharmacy, RIPER- Autonomous, Ananthapuramu, Andhra Pradesh, India.en_US
dc.identifier.affiliationsDepartment of Industrial Pharmacy, RIPER- Autonomous, Ananthapuramu, Andhra Pradesh, India.en_US
dc.identifier.affiliationsDepartment of Industrial Pharmacy, RIPER- Autonomous, Ananthapuramu, Andhra Pradesh, India.en_US
dc.identifier.affiliationsDepartment of Industrial Pharmacy, RIPER- Autonomous, Ananthapuramu, Andhra Pradesh, India. 8Department of Industrial Pharmacy, RIPER- Autonomous, Ananthapuramu, Andhra Pradesh, India.en_US
dc.identifier.citationHarsha wamygari Satya, Ahad Hindustan Abdul, Haranath Chinthaginjala, Dasari Rahul Raghav, Gowthami Madana, Varam Naga Jyothi, Bitranganti Samhitha Rao, Musa Gamaa Birir Mohamed. Exfoliation Technique of Composing and Depictions of Clopidogrel Bisulphate Afloat Microspheres. Journal of Evolution of Medical and Dental Sciences. 2020 Apr; 9(14): 1156-1160en_US
dc.identifier.issn2278-4802
dc.identifier.issn2278-4748
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214806
dc.languageenen_US
dc.publisherAkshantala Enterprises Private Limiteden_US
dc.relation.issuenumber14en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.14260/jemds/2020/251en_US
dc.subjectClopidogrel Bisulphateen_US
dc.subjectCarrageenanen_US
dc.subjectBuoyancyen_US
dc.subjectDischargeen_US
dc.titleExfoliation Technique of Composing and Depictions of Clopidogrel Bisulphate Afloat Microspheresen_US
dc.typeJournal Articleen_US
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