Coronavirus disease 19 (COVID-19) and viral keratouveitis – unraveling the mystery

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dc.contributor.authorSanjay, Srinivasanen_US
dc.contributor.authorKundu, Gairiken_US
dc.contributor.authorDeshpande, Vrushalien_US
dc.contributor.authorSethu, Swaminathanen_US
dc.contributor.authorAgrawal, Ruchikaen_US
dc.contributor.authorGhosh, Arkasubhraen_US
dc.contributor.authorKawali, Ankushen_US
dc.contributor.authorMahendradas, Padmamalinien_US
dc.contributor.authorShetty, Rohiten_US
dc.date.accessioned2023-08-25T06:38:02Z
dc.date.available2023-08-25T06:38:02Z
dc.date.issued2023-08
dc.description.abstractTo demonstrate viral proteins/inflammatory cytokines in a patient with unilateral keratouveitis. Retrospective case report. A 70-year-old Asian-Indian male presented with acute onset of blurring of vision in the left eye (OS) of 2 days duration. He had was coronavirus disease 2019 (COVID-19)-positive 3 months earlier. He had undergone cataract surgery/retinal laser photocoagulation in both the eyes. The corrected distance visual acuity (CDVA) (Snellen) in the right eye (RE) (OD) and left eye (LE) (OS) was 20/20 and 20/80, respectively. OS showed decreased corneal sensation, Descemet’s folds, mild stromal edema, and fine and pigmented keratic precipitates with anterior chamber 1+ flare and 1+ cells. Fundus evaluation showed scattered laser marks in the OD and temporal sectoral laser marks in OS. He was diagnosed with viral keratouveitis in OS. Tear samples were collected on Schirmer’s strips and tear wash for mass spectrometry and cytokines, which had 368 and 451 viral proteins in the RE and LE, respectively, using nano liquid chromatography–mass spectrometry, which were more than controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and varicella zoster virus proteins were detected. Cytokine analysis using flow cytometer analysis showed higher inflammation in OS as compared to OD. The patient was treated with oral acyclovir and topical steroids and resulted in resolution of his keratouveitis. SARS-CoV-2 proteins were present in the tear sample 3 months after COVID-19. The presence of viral proteins does not indicate causalityen_US
dc.identifier.affiliationsDepartment of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of GROW Lab, Narayana Nethralaya Foundation, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Cornea and Refractive Surgery, Neuro-ophthalmology, Narayana Nethralaya, Bangalore, Karnataka, Indiaen_US
dc.identifier.citationSanjay Srinivasan, Kundu Gairik, Deshpande Vrushali, Sethu Swaminathan, Agrawal Ruchika, Ghosh Arkasubhra, Kawali Ankush, Mahendradas Padmamalini, Shetty Rohit. Coronavirus disease 19 (COVID-19) and viral keratouveitis – unraveling the mystery. Indian Journal of Ophthalmology. 2023 Aug; 71(8): 3103-3108en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225188
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber8en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_593_23en_US
dc.subjectCoronavirus disease (COVID?19)en_US
dc.subjectHerpes zosteren_US
dc.subjecttear cytokinesen_US
dc.subjecttear proteonomicsen_US
dc.subjectviral keratouveitisen_US
dc.titleCoronavirus disease 19 (COVID-19) and viral keratouveitis – unraveling the mysteryen_US
dc.typeJournal Articleen_US
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