Childhood Chronic Myeloid Leukemia with Monocytosis.
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Date
2010-10
Journal Title
Journal ISSN
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Abstract
We report two cases of chronic myeloid leukemia
(CML) in childhood presenting with monocytosis. History,
physical examination and laboratory findings were in favor
of juvenile myelomonocytic leukemia in both the cases, but
reverse transcriptase polymerase chain reaction (RT-PCR)
detected b2a2 and b3a2 transcript of p210 bcr-abl protein
characteristic of major BCR breakpoint. Presence of
monocytosis in early childhood suggests a viral infection
or JMML but a possibility of CML with monocytosis needs
to be considered.
Description
Keywords
CML, Monocytosis, Major BCR breakpoint
Citation
Gupta Nidhi, Gupta Ritu, Sharawat Surender Kumar, Bakhshi Sameer. Childhood Chronic Myeloid Leukemia with Monocytosis. Indian Journal of Pediatrics. 2010 Oct; 77 (10): 1143-1146.